2. Disclosure belangen NHG spreker
(Potentiële) belangenverstrengeling
Voor bijeenkomst mogelijk relevante relaties met bedrijven
Andere relatie, namelijk …
I’m an employee and shareholder of Janssen Pharmaceuticals

3. Pneumococcal vaccination associated with fewer episodes of acute otitis media in Dutch children
Alexandre Fortanier

4. Research questions What is the impact of PCV on AOM and its severity?
Does age modify the effect?

5. Study population Primary care (ZGA and LRGP) health records
Children born between
Only those registered at GP within 6 months
Children prospectively followed until:
censor date (age 5 years)
end of registration at GP practice
end of study period

6. Analysis and outcome measures
Negative binomial model using GEE
Primary care follow-up: offset variable
Count = IRR; binary = RR
Outcome measures
Acute otitis media (ICPC H71)
Recurrent AOM (rAOM)
AOM treated with (topical) antibiotics
AOM-related specialist referrals

7. Results Descriptives # Children 18,237 65,678 PY # AOM episodes 16,351
8,867 with (topical) antibiotics
# Children with AOM
7,355
5,616 with (topical) antibiotics
1,200 with referral
711 with rAOM
IRR (95% CI)
post- versus pre-PCV
Interaction with age
AOM episodes
0.93 (0.86 to 1.00)
No, P=0.24
RR (95% CI)
post- versus pre-PCV
Interaction with age
rAOM
0.91 (0.72 to 1.14)
AOM treated
0.97 (0.90 to 1.05)
AOM with referral
1.15 (0.94 to 1.40)

8. Acknowledgements evidENT, University College London, United Kingdom
Anne Schilder, MD, PhD
Julius Center, University Medical Center Utrecht, the Netherlands
Arno Hoes, MD, PhD
Roger Damoiseaux, MD, PhD
Roderick Venekamp, MD, PhD
Marieke de Hoog, PhD
Rebecca Stellato, MSc
National Institute for Public Health and the Environment (RIVM) and UMC Utrecht, the Netherlands
Lieke Sanders, MD, PhD