Presentation is loading. Please wait.

Presentation is loading. Please wait.

Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer  Anekant Jain, MPharm, Sanjay.

Published byRandolph Ross Modified over 6 years ago

Similar presentations

Presentation on theme: "Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer  Anekant Jain, MPharm, Sanjay."— Presentation transcript:

1 Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer  Anekant Jain, MPharm, Sanjay K. Jain, PhD, N. Ganesh, PhD, Jaya Barve, MSc, Aadil M. Beg, BUMS  Nanomedicine: Nanotechnology, Biology and Medicine  Volume 6, Issue 1, Pages (February 2010) DOI: /j.nano Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 Mechanistic scheme of colon-specific targeting of Eudragit-coated pellets encapsulating nanoparticles (arbitrary scale). Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

3 Figure 2 Photomicrographs of chitosan nanoparticles. (A) SEM analysis and (B) TEM analysis of uncoupled nanoparticles. (C) TEM analysis of HA-coupled nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

4 Figure 3 Formulations with different ratios of nanoparticles (NP) and HA were prepared. (A) Incubation time optimization for coupling of HA at 25°C. (B) Optimization of total NP/HA weight ratio (zeta potential values after time period of 24 hours at 25°C). All values are expressed as mean ± SD (n = 4). Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

5 Figure 4 FT-IR spectra of (A) L-OHP, (B) chitosan, (C) drug-bearing uncoupled nanoparticles, and (D) HA-coupled drug-bearing nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

6 Figure 5 DSC curve of (A) L-OHP, (B) HA, (C) HA with drug-polymer mixture, and (D) L-OHP–loaded HA-conjugated HACTNPOP formulations, (E) L-OHP–loaded HACTNPOP formulations after storage at 40°C and 75% relative humidity for 6 months. Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

7 Figure 6 XRDs of (A) L-OHP, (B) blank nanoparticles (HACTNPs), (C) L-OHP–loaded HACTNPOPs, and (D) L-OHP–loaded HACTNPOPs after storage at 40°C and 75% relative humidity for 6 months. Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

8 Figure 7 In vitro drug release profile of nanoparticulate pellets (HACTNPOEPs and CTNPOEPs) in different simulated fluids. SCF, simulated colon fluid; SGF, simulated gastric fluid; SIF, simulated intestinal fluid. Results are presented as mean ± SD, n = 4. Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

9 Figure 8 Distribution profiles of free drug and of uncoupled nanoparticles and HA-coupled nanoparticles bearing L-OHP in various tissues as a function of time after oral dose (10 mg/kg) to mice. (A) Pellets of free L-OHP; (B) CTNPOEPs; (C) HACTNPOEPs. represent mean ± SD obtained from two animals per time point. Colon (+C)⁎, includes colon contents and tissue, cecal contents, and tissue; OXA, oxaliplatin; SI, small intestine. Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

10 Figure 9 γ-scintigraphs captured at different time intervals. (A) Just after administration of pellet showing integrity of the system in stomach. (B) At 1 hour showing the presence of intact enteric-coated pellet in stomach. (C) At 3 hours showing the enteric-coated pellet in small intestine. (D) At 6 hours showing the release of tracer in ascending colon from enteric-coated pellet. (E) At 10 hours showing the release of tracer in ascending colon and entry of pellet mass into transverse colon. (F) At 18 hours showing the distribution of liberated radioactivity in whole colon from enteric-coated pellet. (G) At 24 hours showing the radioactivity in distal part of colon from enteric-coated pellet. Nanomedicine: Nanotechnology, Biology and Medicine 2010 6, DOI: ( /j.nano ) Copyright © 2010 Elsevier Inc. Terms and Conditions

Download ppt "Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer  Anekant Jain, MPharm, Sanjay."

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages 275-291 (March 2014) DOI: 10.1016/j.stem.2014.02.006.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages 248-252 (April 2010) DOI: 10.1016/j.cmet.2010.03.008 Copyright © 2010.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
Probing for chemotherapy-induced peripheral neuropathy in live dorsal root ganglion neurons with atomic force microscopy  Ngan Pan Bennett Au, BS, Yuqiang.

Probing for chemotherapy-induced peripheral neuropathy in live dorsal root ganglion neurons with atomic force microscopy  Ngan Pan Bennett Au, BS, Yuqiang.
On-demand drug release and hyperthermia therapy applications of thermoresponsive poly-(NIPAAm-co-HMAAm)/polyurethane core-shell nanofiber mat on non-vascular.

On-demand drug release and hyperthermia therapy applications of thermoresponsive poly-(NIPAAm-co-HMAAm)/polyurethane core-shell nanofiber mat on non-vascular.
A new opportunity for nanomedicines: Micellar cytochrome P450 inhibitors to improve drug efficacy in a cancer therapy model  Marion Paolini, Laurence.

A new opportunity for nanomedicines: Micellar cytochrome P450 inhibitors to improve drug efficacy in a cancer therapy model  Marion Paolini, Laurence.
Mark A. Munger, PharmD, Przemyslaw Radwanski, PharmD, PhD, Greg C

Mark A. Munger, PharmD, Przemyslaw Radwanski, PharmD, PhD, Greg C
Himanshu Gupta, B. Pharm, M. Pharm, Mohammed Aqil, M

Himanshu Gupta, B. Pharm, M. Pharm, Mohammed Aqil, M
Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers  Keerti Jain, M. Pharm., Ph.D., Ashwni Kumar.

Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers  Keerti Jain, M. Pharm., Ph.D., Ashwni Kumar.
Delia Danila, PhD, Evan Johnson, MS, Patrick Kee, MD, PhD 

Delia Danila, PhD, Evan Johnson, MS, Patrick Kee, MD, PhD 
Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment  Guifa Xi, MD, PhD, Erik Robinson, PhD, Barbara Mania-Farnell,

Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment  Guifa Xi, MD, PhD, Erik Robinson, PhD, Barbara Mania-Farnell,
Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors 

Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors 
Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer  Jing Tian, PhD, Yuangzeng.

Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer  Jing Tian, PhD, Yuangzeng.
Quantum dot-based lab-on-a-bead system for multiplexed detection of free and total prostate-specific antigens in clinical human serum samples  Kristina.

Quantum dot-based lab-on-a-bead system for multiplexed detection of free and total prostate-specific antigens in clinical human serum samples  Kristina.
From solvent-free microspheres to bioactive gradient scaffolds

From solvent-free microspheres to bioactive gradient scaffolds
Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine  Cassilda Pereira,

Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine  Cassilda Pereira,
Nanomedicine: Nanotechnology, Biology and Medicine

Nanomedicine: Nanotechnology, Biology and Medicine
Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy  Shengpeng.

Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy  Shengpeng.

Similar presentations

Ads by Google