1. LYMPHADENECTOMY IN UROTHELIAL CARCINOMA IN THE RENAL PELVIS AND URETER
A RANDOMIZED INTERNATIONAL CLINICAL TRIAL ON LYMPHADENECTOMY IN UROTHELIAL CARCINOMA IN THE RENAL PELVIS AND URETER
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2. Inclusion criteria
Subjects must provide written informed consent prior to performance of study-specific
procedures or assessments, and must be willing to comply with treatment and follow-up.
Age ≥ 18 years
Eastern Cooperative Oncology Group (ECOG) status of 0-2.
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3. Histological defined UTUC: Histologically confirmed diagnosis of predominantly urothelial carcinoma of the upper urinary tract.
Yes
Positive biopsy for high grade tumor No
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4. Histological defined UTUC: Histologically confirmed diagnosis of predominantly urothelial carcinoma of the upper urinary tract.
Yes
Selective upper tract positive cytology No
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5. Histological defined UTUC: Histologically confirmed diagnosis of predominantly urothelial carcinoma of the upper urinary tract.
Yes
Micturition positive cytology (if there is no bladder cancer simultaneously) No
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6. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
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Pelvic or calyx tumor Upper 2/3 of ureter
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7. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
Yes
Absence of fat between pelvis and kidney No
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8. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
Yes
Evidence of parenchymal invasion No
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9. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
Yes
Growing of tumor out of the renal pelvis No
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10. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
Yes
Tumor > 1 cm No
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11. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
Yes
Growing of the tumor out of the ureter No
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12. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
Yes
Dilation grade 3-4 No
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13. Radiological defined UTUC: Patients with UTUC cT2-T4, N0- M0 (TNM classification): Criteria must to be defined by radiologists.
Yes
Tumor > 1 cm No
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14. Can not included in the study
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15. Randomization
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