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Published byMarlene Smith Modified over 6 years ago
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From: Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats Anesthes. 2009;110(6): doi: /ALN.0b013e31819fccd5 Figure Legend: Fig. 5. Anti-interleukin (IL)-10 antibody dose-dependently reverses the amitriptyline-induced upregulation of phospho -p38 mitogen-activated protein kinase (MAPK) and heme oxygenase (HO)-1 expression in amitriptyline/morphine-coinfused rats. ( A ) Western blot of phospho -p38 MAPK and HO-1 in the spinal cord dorsal horn of the different treatment groups; β-actin was used as the internal standard (n = 4 of each group). ( B ) Relative band densities for the phospho -p38 MAPK and HO-1 after the different treatments; the results are the mean ± SEM. CONT = saline infusion; MO+AMI = morphine plus amitriptyline coinfusion; MO+AMI/Anti-IL-10Ab = morphine plus amitriptyline coinfusion plus anti-IL-10 antibody injection for 5 days. *** P < compared with saline-infused control group; +++ P < compared with amitriptyline/morphine-coinfused group. Date of download: 10/7/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.
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