1. Animal Biotechnology

2. Uses of Genetically Engineered Animals
Develop new medical treatments
Improve food supply
Enhance our understanding of animals
(Humans are animals)

3. Animal Models
Animal research has been key to nearly every major medical breakthrough of the last century
Required in FDA testing
Several common species
Alternatives to animal models

4. Cloning

5. How are transgenic animals made?
Retrovirus-mediated transgenesis
Pronuclear microinjection
Embryonic Stem Cell Method
Sperm-mediated transfer
Gene guns

6. Pronuclear Microinjection

7. Application of Transgenic Animals
“Miracle Grow” Chickens
Healthier eggs
Dairy industry
Disease reduction in livestock
Reducing human food poisoning

8. Transgenic Animals as Bioreactors
Use animals to produce proteins
Use transgenics to introduce the gene of interest
Examples
BioSteel
ATryn gene

9. Knockout (& Knockin) Animals

10. Monoclonal Antibodies