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Indermeet Kohli, PhD, Rubina Shafi, PhD, Prescilia Isedeh, MD, James L

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Presentation on theme: "Indermeet Kohli, PhD, Rubina Shafi, PhD, Prescilia Isedeh, MD, James L"— Presentation transcript:

1 The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study 
Indermeet Kohli, PhD, Rubina Shafi, PhD, Prescilia Isedeh, MD, James L. Griffith, MD, Mohammed S. Al-Jamal, MD, Narumol Silpa- archa, MD, Bradford Jackson, PhD, Mohammed Athar, PhD, Nikiforos Kollias, PhD, Craig A. Elmets, MD, Henry W. Lim, MD, Iltefat H. Hamzavi, MD  Journal of the American Academy of Dermatology  Volume 77, Issue 1, Pages e1 (July 2017) DOI: /j.jaad Copyright © Terms and Conditions

2 Fig 1 Ultraviolet B response. Pre-Polypodium leucotomos extract (PLE) minimal erythema dose (MED) site 1 (left) and post-PLE MED site 2 (right); set of representative clinical photographs demonstrating an increase in MED for a subject from 100 mJ/cm2 pre-PLE to 150 mJ/cm2 post-PLE administration. Journal of the American Academy of Dermatology  , e1DOI: ( /j.jaad ) Copyright © Terms and Conditions

3 Fig 2 Ultraviolet B response. Average erythema investigator global assessment (IGA) scores. Mean ± SE of the mean. Asterisk, Statistically significant change (P < .05). PLE, Polypodium leucotomos extract. Journal of the American Academy of Dermatology  , e1DOI: ( /j.jaad ) Copyright © Terms and Conditions

4 Fig 3 Ultraviolet (UV)B response. A, Average pre- and post-Polypodium leucotomos extract (PLE) relative erythema intensity. Mean ± SE of the mean. Asterisk, Statistically significant change (P < .05). B, Pre-PLE minimal erythema dose (MED) site 2, 150 mJ/cm2 (left), post-PLE MED site 2, 150 mJ/cm2 (right); set of representative clinical photographs demonstrating the decrease in erythema intensity although no change in MED. C, Pre- and post-PLE relative erythema intensity as a function of UVB dose for 1 subject. Mean ± SD. The pre-PLE MED for this subject was 100 (linear range 50–280 mJ/cm2) and post-PLE MED was 150 (linear range  mJ/cm2). Although all data points have been shown in the graph, slopes were calculated corresponding to the linear section only. D, Average pre- and post-PLE relative erythema intensity for all subjects as a function of UVB doses. Mean ± SE of the mean. Journal of the American Academy of Dermatology  , e1DOI: ( /j.jaad ) Copyright © Terms and Conditions

5 Fig 4 Ultraviolet (UV)B response. Changes in biomarkers of UV radiation exposure before and after Polypodium leucotomos extract (PLE). A, Stained nuclei for cyclobutane pyrimidine dimers (CPD), Ki67, proliferating cell nuclear antigen (PCNA), and cyclin D1. B, Sunburn cells and cytoplasmic staining for cyclooxygenase-2 (COX-2). Representative photomicrographs. (Original magnifications: ×20.) Journal of the American Academy of Dermatology  , e1DOI: ( /j.jaad ) Copyright © Terms and Conditions

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