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Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers  Keerti Jain, M. Pharm., Ph.D., Ashwni Kumar.

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Presentation on theme: "Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers  Keerti Jain, M. Pharm., Ph.D., Ashwni Kumar."— Presentation transcript:

1 Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers  Keerti Jain, M. Pharm., Ph.D., Ashwni Kumar Verma, PhD, Prabhat Ranjan Mishra, PhD, Narendra Kumar Jain, PhD  Nanomedicine: Nanotechnology, Biology and Medicine  Volume 11, Issue 3, Pages (April 2015) DOI: /j.nano Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic representation of synthesis of MdPPI conjugates.
Nanomedicine: Nanotechnology, Biology and Medicine  , DOI: ( /j.nano ) Copyright © 2015 Elsevier Inc. Terms and Conditions

3 Figure 2 TEM photograph of MdPPI conjugate.
Nanomedicine: Nanotechnology, Biology and Medicine  , DOI: ( /j.nano ) Copyright © 2015 Elsevier Inc. Terms and Conditions

4 Figure 3 Hemolytic toxicity of various AmB formulations. Values represent mean±S.D. (n=3). Nanomedicine: Nanotechnology, Biology and Medicine  , DOI: ( /j.nano ) Copyright © 2015 Elsevier Inc. Terms and Conditions

5 Figure 4 Cytotoxicity of different formulations of AmB against J774A.1 cells. Values represent mean±S.D. (n=3). Nanomedicine: Nanotechnology, Biology and Medicine  , DOI: ( /j.nano ) Copyright © 2015 Elsevier Inc. Terms and Conditions

6 Figure 5 Qualitative and quantitative uptake of AmB and MdPPIA by J774A.1 cells (P<0.001 for AmB and MdPPIA). Values represent mean±S.D. (n=3). Nanomedicine: Nanotechnology, Biology and Medicine  , DOI: ( /j.nano ) Copyright © 2015 Elsevier Inc. Terms and Conditions

7 Figure 6 Antileishmanial activity of AmB formulations Values represent mean±S.D. (n=6). Nanomedicine: Nanotechnology, Biology and Medicine  , DOI: ( /j.nano ) Copyright © 2015 Elsevier Inc. Terms and Conditions

8 Nanomedicine: Nanotechnology, Biology and Medicine 2015 11, 705-713DOI: (10.1016/j.nano.2014.11.008)
Copyright © 2015 Elsevier Inc. Terms and Conditions

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