Download presentation
Presentation is loading. Please wait.
Published byShawn Lesley Manning Modified over 7 years ago
1
Neurophysiological correlates of metabolic syndrome and cognitive impairment in schizophrenia: A structural equation modeling approach Laurent Boyer, Julien Testart, Pierre Michel, Raphaëlle Richieri, Catherine Faget-Agius, Violette Vanoye, Pascal Auquier, Christophe Lancon, Eric Guedj Psychoneuroendocrinology Volume 50, Pages (December 2014) DOI: /j.psyneuen Copyright © 2014 Elsevier Ltd Terms and Conditions
2
Figure 1 Anatomical localization of significant SPECT findings in comparison to healthy subjects (voxel level significance of p<0.005, uncorrected; p<0.05 for the cluster, uncorrected). Bilateral fronto-temporal hypoperfusions were found in patients, in comparison to healthy subjects, with wider abnormalities in patients with metabolic syndrome, than those without. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) Psychoneuroendocrinology , DOI: ( /j.psyneuen ) Copyright © 2014 Elsevier Ltd Terms and Conditions
3
Figure 2 Anatomical localization of significant SPECT findings between patients (voxel level significance of p<0.005, uncorrected; p<0.05 for the cluster, uncorrected). (A) Hypoperfusions in patients with metabolic syndrome, in comparison to those without, on SPM surface rendered. (B) Increase of functional connectivity with left frontal region in patients with metabolic syndrome, in comparison to those without, on SPM surface rendered. (A) In comparison to patients without metabolic syndrome, those with metabolic syndrome exhibited significant hypoperfusion within the left orbital prefrontal cortex (inferior and superior frontal gyrus, BA11 and BA47). (B) Functional connectivity from this left frontal cluster was significantly increased in patients with metabolic syndrome within the left insula (BA13) and left middle/superior frontal gyrus (BA11), in comparison to patients without metabolic syndrome. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) Psychoneuroendocrinology , DOI: ( /j.psyneuen ) Copyright © 2014 Elsevier Ltd Terms and Conditions
4
Figure 3 Structural equation model: hypothesized model with fitted coefficients for schizophrenia patients with metabolic syndrome. Psychoneuroendocrinology , DOI: ( /j.psyneuen ) Copyright © 2014 Elsevier Ltd Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.