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Engineered antibodies: A new tool for use in diabetes research

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Presentation on theme: "Engineered antibodies: A new tool for use in diabetes research"— Presentation transcript:

1 Engineered antibodies: A new tool for use in diabetes research
Carolyn J. Padoa, Nigel J. Crowther  Diabetes Research and Clinical Practice  Volume 74, Issue 2, Pages S51-S62 (November 2006) DOI: /j.diabres Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Structure of an IgG molecule (adapted from Kim et al. [92]).
Diabetes Research and Clinical Practice  , S51-S62DOI: ( /j.diabres ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 A schematic representation of the genes coding for antibodies (adapted from Milstein [6]). Diabetes Research and Clinical Practice  , S51-S62DOI: ( /j.diabres ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Heavy chain gene rearrangement and alternative forms of splicing of precursor RNA (adapted from Milstein [6]). Diabetes Research and Clinical Practice  , S51-S62DOI: ( /j.diabres ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Schematic representation of recombinant antibody constructs (adapted from Kim et al. [92]). Diabetes Research and Clinical Practice  , S51-S62DOI: ( /j.diabres ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 Generation of antibodies by phage technology (adapted from Marks et al. [93]). Diabetes Research and Clinical Practice  , S51-S62DOI: ( /j.diabres ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions


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