1. New Approaches to Metabolomics Research
Institute for Clinical and Translational Research
And
Translational Laboratory Cores
Craig Hendrix, MD, ICTR/CFAR Lab Core Director
Curt Reynolds, MAS, ICTR/CFAR Lab Core Project Manager

2. What can ICTR do for you? http://ictr.johnshopkins.edu/
Organized into 6 Cores
Translational Laboratory Core (TLC)
Human Subjects Research Core
Quantitative Methodologies Core
Informatics Core
Research Participant and Community Partnership Core
Education, Training and Career Development Core
…and 2 stand-alone programs
The Studio/Navigation Program
Translational Research Communities

3. Pilot Funding http://ictr.johnshopkins.edu/
Objective: Targeted Funding & Engaged Management to Advance Translational Research
Accelerated Translational Incubator Program (ATIP)
Funding requests one to two times per year.
Approximately 5-10 awards made per year.
Awards up to $100,000 in direct costs (no salary support)
12-month accelerated funding period
Nexus Awards
Gap targeted RFA from each Research community
Biomarker and Diagnostic Testing
Drugs/Biologics/Vaccines/Devices
Behavioral, Social, and Systems Science
Funding/timing similar to ATIP

4. Pilot Funding http://ictr.johnshopkins.edu/
Doris Duke Early Clinical Investigator Award
1 – 2 years of funding of $30,000 – 40,000 per year to fund salary or other research support needs
Comprehensive support program that integrates supplemental financial resources with guidance for career development services, and ongoing mentoring. Support may include:
Salary support for research coordinator, biostatistician, data base specialist, help with access to clinical data, writer;
Salary support to allow more research time (e.g., reduce clinical obligations)
SOM Discovery Fund For Synergy and Innovation Award
Provide grant awards to cross-divisional teams, comprised of faculty and/or non-faculty members from at least two schools or affiliates of the university, who are poised to arrive at important discoveries or creative works.
The expectation is that these awards will spark new, synergistic interactions between investigators across the institution and lead to work of the highest quality and impact.

5. Translational Laboratory Core (TLC)
Provide state-of-the-art conceptual and technical laboratory support
Deliver services to translational scientists
Priority to ATIP developmental grants, junior, and new translational scientists
11 service core laboratories provide:
Consultation
Assay development
Sample analysis
Coordination with ICTR Clinical Services, Studios, Communities
Costs subsidized; depend on investigator funding

6. TLC Laboratories Drug Development Resources & Services
Drug Analysis Units
Assay development, sample analysis, pharmacokinetics, pre-clinic study design
Oncology Michelle Rudek , )
Clinical Pharmacology Analytical Lab (CPAL) Mark Marzinke )
Medicinal Chemistry Unit David Meyers , )
Small molecule synthesis, supports structure-activity relationship studies
Drug Screening Library Unit Jun Liu )
FDA approved drug library; repurposing licensed drugs

7. TLC Laboratories Drug Development Resources & Services (Continued)
Johns Hopkins Drug Discovery Research Consultancy and Services
Barbara Slusher )
Offers consultants based on 18 years of Pharma industry experience. The program has interactions and connections with the pharma, biotech and venture community.
Medicinal Chemistry Unit: Takashi Tsukamoto
Assay development Unit: Camilo Rojas
Drug Metabolism & Pharmacokinetics Unit: Rana Rais
In vivo Pharmacology Unit: Krystyna Wozniak
Drug Development Unit Craig Hendrix )
Consultative support for early clinical drug development
Protocol design, data analysis, clinical study support

8. TLC Laboratories
Biologics Vic Lemas, Ruth Karron , , )
Biologic product development/testing, GMP cell lines, gene vectors, antibodies, peptides
Proteomics Robert Cole )
Profiling for small molecules, biomarker development, protein analysis
Metabolomics Anne Le )
Analysis of endogenous small molecules, targeted mass spec-based metabolomics
Genetics Garry Cutting )
Genetic based sequencing and diagnostic assays, Clinical assay development
Imaging Kasia Macura )
Facilitates integrated use of imaging resources, image data file storage, & distribution
CRU Core Laboratory Neal Fedarko )
Kit-based assays validated, applied to support clinical studies

10. On The Web - Information http://ictr.johnshopkins.edu
Click on Laboratory Services