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Brainstem cytokine changes in healthy ageing and Motor Neurone Disease

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Presentation on theme: "Brainstem cytokine changes in healthy ageing and Motor Neurone Disease"— Presentation transcript:

1 Brainstem cytokine changes in healthy ageing and Motor Neurone Disease
Anuradha Tennakoon, Viythia Katharesan, Ian P. Johnson  Journal of the Neurological Sciences  Volume 381, Pages (October 2017) DOI: /j.jns Copyright © 2017 Elsevier B.V. Terms and Conditions

2 Fig. 1 Changes in IL-1β, IP-10 and MIP-1β cytokine concentrations in adult, ageing and MND brainstem. IL-1β, IP-10 and MIP-1β levels are significantly higher in ageing controls compared to adult controls, whereas MIP-1β levels are significantly lower in MND compared to ageing controls. Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2017 Elsevier B.V. Terms and Conditions

3 Fig. 2 Remaining 24 brainstem cytokine concentrations in adult, ageing and MND brainstem. Significant differences are seen between all 3 groups for 7 cytokine -1ra, IL-6, TNF-α, IL-8, IL-15, IL-2 and IL-4 but post-hoc tests failed to show significant differences for individual cytokines between groups. Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2017 Elsevier B.V. Terms and Conditions

4 Fig. 3 Dot-plot graphs of 27 brainstem cytokine concentrations in adult, ageing and MND brainstem. Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2017 Elsevier B.V. Terms and Conditions

5 Fig. 4 MIP-1β expression in GFAP-positive astrocytes in adult, ageing and MND mid/lower pons. Note that it is not possible to assess changes in overall GFAP or MIP-1β immunostaining intensity in the small areas shown here (see Figs 5 and 6). Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2017 Elsevier B.V. Terms and Conditions

6 Fig. 5 Intensity of MIP-1β immunostaining. MIP-1β fluorescence intensity is increased in ageing control brainstem compared to adult controls, but not in MND brainstem. Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2017 Elsevier B.V. Terms and Conditions

7 Fig. 6 Intensity of GFAP immunostaining. No significant changes in GFAP fluorescence intensity are found between the groups. Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2017 Elsevier B.V. Terms and Conditions

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