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Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor.

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Presentation on theme: "Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor."— Presentation transcript:

1 Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma  Makoto Hoshino, MD, Miki Takahashi, MD, Yujiro Takai, MD, JaeJoon Sim, MD  Journal of Allergy and Clinical Immunology  Volume 104, Issue 2, Pages (August 1999) DOI: /S (99) Copyright © 1999 Mosby, Inc. Terms and Conditions

2 Fig. 1 Effects of treatment with BDP or placebo on the percentage expression of MMP-9 and TIMP-1 in the bronchial mucosa. Horizontal bars represent median values (A, epithelium; B, submucosa). Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions

3 Fig. 2 Expression of MMP-9 (A and B ) and TIMP-1 (C and D ) in bronchial biopsy specimens before (A and C ) and after (B and D ) treatment with BDP. Journal of Allergy and Clinical Immunology  , DOI: ( /S (99) ) Copyright © 1999 Mosby, Inc. Terms and Conditions


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