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The Association of Dietary Alpha-Linolenic Acid with Blood Pressure and Subclinical Atherosclerosis in People Born Small for Gestational Age: The Special.

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Presentation on theme: "The Association of Dietary Alpha-Linolenic Acid with Blood Pressure and Subclinical Atherosclerosis in People Born Small for Gestational Age: The Special."— Presentation transcript:

1 The Association of Dietary Alpha-Linolenic Acid with Blood Pressure and Subclinical Atherosclerosis in People Born Small for Gestational Age: The Special Turku Coronary Risk Factor Intervention Project Study  Michael R. Skilton, PhD, Katja Pahkala, PhD, Jorma S.A. Viikari, MD, PhD, Tapani Rönnemaa, MD, PhD, Olli Simell, MD, PhD, Antti Jula, MD, PhD, Harri Niinikoski, MD, PhD, David S. Celermajer, PhD, FRACP, Olli T. Raitakari, MD, PhD  The Journal of Pediatrics  Volume 166, Issue 5, Pages e2 (May 2015) DOI: /j.jpeds Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 A, SBP, B, PP, and C, BMI in children born SGA (×) and children born with normal birth weight (●). Data shown only for 7, 13, and 18 months, and then annually from 2 to 19 years of age. Adjusted for sex, intervention group, maternal and paternal age at birth; blood pressure models further adjusted for height and adiposity. The Journal of Pediatrics  , e2DOI: ( /j.jpeds ) Copyright © 2015 Elsevier Inc. Terms and Conditions

3 Figure 4 Aortic IMT at age 19 years, and tertiles of average dietary ALA intake throughout childhood, in those born SGA (×) and normal birth weight (●). Ptrend = .001 for SGA; Ptrend = .68 for normal birth weight. Data are mean (95% CI), adjusted for sex, randomized group, maternal and paternal age at birth, and aortic diameter at end diastole. The Journal of Pediatrics  , e2DOI: ( /j.jpeds ) Copyright © 2015 Elsevier Inc. Terms and Conditions

4 Figure 2 Cardiometabolic risk factors in people born SGA (×), and with normal birth weight (●). Results are mean (95% CI), or geometric mean (95% CI) for log-transformed variables (insulin and hs-CRP); derived from all measures during childhood and adolescence. HOMA-IR, homeostatic model assessment of insulin resistance. The Journal of Pediatrics  , e2DOI: ( /j.jpeds ) Copyright © 2015 Elsevier Inc. Terms and Conditions

5 Figure 3 Aortic IMT at age 19 years, and average ALA intake throughout childhood, in those born A, SGA (×) and B, normal birth weight (●). Pinteraction = .01. Adjusted for sex, randomized group, maternal and paternal age at birth, and aortic diameter at end diastole. The Journal of Pediatrics  , e2DOI: ( /j.jpeds ) Copyright © 2015 Elsevier Inc. Terms and Conditions


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