1. Prozac
Emina Hodzic
period 3

2. Names and Chemical Formula
Prozac (Fluoxetine Hydrochloride)
IUPAC name= N-methyl-3-phenyl-3-[4- (trifluoromethyl)phenoxy]propan-1-amine
Formula=C17H18F3NO
Street names= happy pills / bottled smiles 

3. Classification Antidepressant
Selective Serotonin Reuptake Inhibitors (SSRIs).
Schedule IV drug
Currently accepted medical use in treatment in the U.S
Low potential for abuse

4. History of Prozac 1970s – Eli Lilly and Co.
Organic Chemists were working on finding new compounds that showed activity at serotonin receptor sites.
Came across (fluoxetine)
Continued in 1980s
Zimelidine (serotonin uptake blocker) was tested in rats and found that it helped with the addiction of morphine and alcohol.
Found that drugs that increase concentrations of brain serotonin cause animals/humans to drink less alcohol and resulted in weight loss.
Already had the name Prozac picked out.
Became secret investigation when Prozac was classified as an antidepressant instead.
Approved by the FDA in 1987

5. Production Prozac is made from almost entirely from fluoride.
Fluoride is the main ingredient in rat and cockroach poisons, anesthetic ,hypnotic and psychiatric drugs, and military nerve gas.
Synthetic drug
One of the most prescribed drugs in U.S
Leading antidepressant

6. Common Abusers Taken Orally (pill form) Prescription is needed
Available in 10mg, 20mg and 40mg doses
Found in tablets/capsules
When abused, some cases result in amphetamine like effects, and increases energy
Abuse Drug by:
Overdose
Mix with alcohol

7. Affects Insomnia Irritability Nervousness and anxiety
Violent thoughts and actions
Agitation
Suicidal thoughts or suicide
Tremors
Hostility
Sweating
Irregular heartbeat
Aggression
Criminal behavior
Confusion and incoherent thoughts
Paranoia
Hallucinations
Psychosis
Akathisia (a painful inner agitation; inability to sit still)

8. Continued… Medical use: -used to treat depression
-obsessive compulsive disorder (OCD)
-Bulimia Nervosa
-Panic Disorder
Prozac is a fluoxetine that affects neurotransmitters
An imbalance in neurotransmitters is the cause of depression

9. Risks Long term use leads to dependence. LD50= 284mg/kg in mice
User goes through withdrawal if they miss a dose or stop taking the drug completely.
Withdrawal symptoms include
Dizziness
Nausea
Headaches
Vomiting
Irritability
Nightmares

10. Detection
While on Prozac, a blood test can be taken to measure serotonin levels.
Used to see if it causes an increase/decrease in serotonin.
Brain biopsy is more accurate.
Prozac stays in the body for a long time.
Test positive for up to 3 months

11. Consequences Prozac is a prescription only drug.
Illegal to sell prescription drugs to other people or get them from other people
Fines
Imprisonment
Treatments:
Counseling
Doctors
Rehab

12. Works Cited
Prozac. (2012). In Drugs.com. Retrieved December 17, 2012, from
MedicineNet, INC. (2012). fluoxetine - oral, Prozac, Sarafem. In MedicineNet.com. Retrieved December 17, 2012, from
Hanson, D. (2009, July). The History of Prozac. In Addicition Inbox. Retrieved December 17, 2012, from dirkh.blogspot.com/2009/07/history-of-prozac.html
Encyclopedia Britannica INC. (2012). Prozac. In Encyclopedia Britannica. Retrieved December 19, 2012, from encyclopedia britannica
Sussex Directories, Inc. (2012). And Prozac For All. In Physcology Today. Retrieved December 19, 2012, from