1. Administrative Overview
Ed Riley, Ph.D.
CIFASD Administrative Core Director
March, 2015

2. Thanks to the 3 J’s for their help in preparing for this meeting

3. Welcome
Kristy Donald
Alison Noble
Joanne Weinberg

4. New CIFASD Developmental Projects
Kirsty Donald - A Neuro- and 3D Facial Imaging Study of 2 Year-Old Children with Alcohol Exposure Compared to Healthy Unexposed Controls Embedded in a Birth Cohort Study
Joanne Weinberg - Identifying an Immune Signature Characteristic of FASD: Implications for Possible Immune- Based Intervention Strategies
Alison Noble (Peter Hammond) - Combining 3D Ultrasound Image Analysis and 3D Facial Morphometry to Detect Craniofacial Effects of Prenatal Alcohol Exposure
Julie Kable - GoFAR Therapy for FASD Children: Prefrontal Blood Oxygenation Changes Using fNIR
Process slide, include if time.
Maybe detail go.

5. CIFASD – International Consortium on FASD
CIFASD – International Consortium on FASD
San Diego State University
Harvard University
University of California, San Diego
Indiana University School of Medicine
Indiana University-Purdue University School of Science
NOFAS, Washington DC
Emory University
University of North Carolina at Chapel Hill
University of Texas, Austin
Texas A&M
University of Minnesota
Rutgers University
Children's Hospital Los Angeles
Oxford University
Ukrainian-American Birth Defects Program
University of British Columbia
University of Cape Town, South Africa, Cape Town

6. Current CIFASD Conceptual Framework
Alcohol Consumption
During
Pregnancy
Embryonic and Fetal Development
Dose
Timing
Pattern
Genetics
Age
Nutrition
Brain
Face
Needs to be prettier
Behavior
Environment
Genetics 6

7. Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)
Clinical Science
Foroud and
Hammond
Basic Science
Sulik and
Parnell
Chambers
Eberhart
Administrative
Riley
Mattson
Miranda
Informatics
Barnett
Dysmorphology
Jones
Kable
Needs to be fixed.
Sowell and
Wozniak
Weinberg
NoFAS
Donaldson
Donald
Noble
Foroud
Noble
Developmental
Projects

8. A Few of Admin Accomplishments
Coordinated monthly conference calls and WebEx
Data Access and Publications Committees revised their forms and procedures, which are now online
Assessed goals in meeting current specific aims – Provided feedback
Collected Progress Reports and distributed these to SAB and NIAAA staff
New Developmental Projects –Drs. Donald, Weinberg, and Kable
Dr. Charness, our Scientific Director, submitted a CIFASD symposium for the 2016 RSA meeting (Charness, Eberhart, Parnell, Wozniak, Chambers). Genes, drugs, money, and vitamins: Cifasd studies of risk and resilience in FASD.
CIFASD has a symposium submitted to ISBRA on early identification of FASD (Drs. Charness, Miranda, Sarkar, Kable, and Donald

9. A Few of Our Accomplishment
E. Riley presented at a Congressional Briefing on FASD – Washington, DC. and at the APSAAR, ESBRA, and Anishinabek G7 meetings
E. Riley did a NIAAA, WHO training in Krakow, Poland
Numerous CIFASD scientists presented at the APA meeting in Toronto, Canada
Numerous CIFASD scientists presented at RSA meeting in San Antonio, TX
E. Riley interviewed for 4-Corners in Australia
Numerous recent interviews covered in several sources by CIFASD investigators (Charness, Mitchell, Chambers, Sowell)

10. Riley Publications Citing Admin Core
Charness, ME, Riley, EP., Sowell, ER. Drinking During Pregnancy and the Developing Brain: Is Any Amount Safe? Trends in Cognitive Neuroscience, 2016, 20,
Gautam P, Nuñez SC, Narr KL, Mattson SN, May PA, Adnams CM, Riley EP, Jones KL, Kan EC, Sowell ER. Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study. Cereb Cortex Dec;25(12): doi: /cercor/bhu162. Epub 2014 Aug 4. PubMed PMID: ; PubMed Central PMCID: PMC
Infante MA, Moore EM, Bischoff-Grethe A, Migliorini R, Mattson SN, Riley EP. Atypical cortical gyrification in adolescents with histories of heavy prenatal alcohol exposure. Brain Res Oct 22;1624: doi: /j.brainres Epub 2015 Aug 12. PubMed PMID: ; PubMed Central PMCID: PMC
Migliorini R, Moore EM, Glass L, Infante MA, Tapert SF, Jones KL, Mattson SN, Riley EP. Anterior cingulate cortex surface area relates to behavioral inhibition in adolescents with and without heavy prenatal alcohol exposure. Behav Brain Res Oct 1;292: doi: /j.bbr Epub 2015 May 27. PubMed PMID: ; PubMed Central PMCID: PMC
Simmons RW, Nguyen TT, Thomas JD, Riley EP. The Use of Open- and Closed-Loop Control During Goal-Directed Force Responses by Children with Heavy Prenatal Alcohol Exposure. Alcohol Clin Exp Res Sep;39(9): doi: /acer Epub 2015 Aug 6. PubMed PMID: ; PubMed Central PMCID: PMC
Moore EM, Riley EP. What Happens When Children with Fetal Alcohol Spectrum Disorders Become Adults? Curr Dev Disord Rep Sep;2(3): Epub 2015 Jun 24. PubMed PMID: ; PubMed Central PMCID: PMC
Infante MA, Moore EM, Nguyen TT, Fourligas N, Mattson SN, Riley EP. Objective assessment of ADHD core symptoms in children with heavy prenatal alcohol exposure. Physiol Behav Sep 1;148: doi: /j.physbeh Epub 2014 Oct 23. PubMed PMID: ; PubMed Central PMCID: PMC
Gautam P, Lebel C, Narr KL, Mattson SN, May PA, Adnams CM, Riley EP, Jones KL, Kan EC, Sowell ER. Volume changes and brain-behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure. Hum Brain Mapp Jun;36(6): doi: /hbm Epub 2015 Feb 25. PubMed PMID: ; PubMed Central PMCID: PMC
Murawski NJ, Moore EM, Thomas JD, Riley EP. Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies. Alcohol Res. 2015;37(1): Review. PubMed PMID: ; PubMed Central PMCID: PMC

11. Other Publications Citing Admin Core
Gautam, P., Lebel, C., Narr, K. L., Mattson, S. N., May, P. A., Adnams, C. M., Sowell, E. R. (2015). Volume changes and brain-behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure. Hum Brain Mapp, 36(6), doi: /hbm.22772
Lee, H. S., Jones, K. L., Lee, H. K., & Chambers, C. D. (2016). Fetal alcohol spectrum disorders: Clinical phenotype among a high-risk group of children and adolescents in Korea. Am J Med Genet A, 170(1), doi: /ajmg.a.37392
Lovely, C. B., Nobles, R. D., & Eberhart, J. K. (2014). Developmental age strengthens barriers to ethanol accumulation in zebrafish. Alcohol, 48(6), doi: /j.alcohol
Rachdaoui, N., & Sarkar, D. K. (2014). Transgenerational epigenetics and brain disorders. Int Rev Neurobiol, 115, doi: /B
Tesche, C. D., Kodituwakku, P. W., Garcia, C. M., & Houck, J. M. (2015). Sex-related differences in auditory processing in adolescents with fetal alcohol spectrum disorder: A magnetoencephalographic study. Neuroimage Clin, 7, doi: /j.nicl
Vakhtin AA, Kodituwakku PW, Garcia CM, and Tesche CD. Aberrant development of post-movement beta rebound in adolescents and young adults with fetal alcohol spectrum disorders. NeuroImage. Clinical, 2015;9: PMCID:PMC

12. Publications from CIFASD 2015-2016
Lindinger NM, Malcolm-Smith S, Dodge NC, Molteno CD, Thomas KG, Meintjes EM, Jacobson JL, Jacobson SW. Theory of Mind in Children with Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res Feb;40(2):
Gilbert MT, Sulik KK, Fish EW, Baker LK, Dehart DB, Parnell SE. Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice. Neurotoxicol Teratol Dec 18. pii: S (15)
Vakhtin AA, Kodituwakku PW, Garcia CM, Tesche CD. Aberrant development of post-movement beta rebound in adolescents and young adults with fetal alcohol spectrum disorders. Neuroimage Clin Sep 18;9:
Doyle LR, Mattson SN. Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Review of Evidence and Guidelines for Assessment. Curr Dev Disord Rep Sep;2(3): Epub 2015 Jun 27. PubMed PMID: ;
Birch SM, Lenox MW, Kornegay JN, Shen L, Ai H, Ren X, Goodlett CR, Cudd TA, Washburn SE. Computed tomography assessment of peripubertal craniofacial morphology in a sheep model of binge alcohol drinking in the first trimester. Alcohol Nov;49(7):
Kable JA, Coles CD, Keen CL, Uriu-Adams JY, Jones KL, Yevtushok L, Kulikovsky Y, Wertelecki W, Pedersen TL, Chambers CD; CIFASD. The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. Alcohol Nov;49(7):
Woods KJ, Meintjes EM, Molteno CD, Jacobson SW, Jacobson JL. Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders. Neuroimage Clin Apr 1;8:
Coles CD, Kable JA, Keen CL, Jones KL, Wertelecki W, Granovska IV, Pashtepa AO, Chambers CD; CIFASD. Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants. Matern Child Health J Dec;19(12):

13. Publications from CIFASD 2015-2016
Donald KA, Roos A, Fouche JP, Koen N, Howells FM, Woods RP, Zar HJ, Narr KL, Stein DJ. A study of the effects of prenatal alcohol exposure on white matter microstructural integrity at birth. Acta Neuropsychiatr Aug;27(4):
du Plessis L, Jacobson SW, Molteno CD, Robertson FC, Peterson BS, Jacobson JL, Meintjes EM. Neural correlates of cerebellar-mediated timing during finger tapping in children with fetal alcohol spectrum disorders. Neuroimage Clin Dec 24;7:
Lewis CE, Thomas KG, Dodge NC, Molteno CD, Meintjes EM, Jacobson JL, Jacobson SW. Verbal learning and memory impairment in children with fetal alcohol spectrum disorders. Alcohol Clin Exp Res Apr;39(4): doi: /acer PubMed PMID: ; PubMed Central PMCID: PMC
Fan J, Meintjes EM, Molteno CD, Spottiswoode BS, Dodge NC, Alhamud AA, Stanton ME, Peterson BS, Jacobson JL, Jacobson SW. White matter integrity of the cerebellar peduncles as a mediator of effects of prenatal alcohol exposure on eyeblink conditioning. Hum Brain Mapp Jul;36(7):
Wieczorek L, Fish EW, O'Leary-Moore SK, Parnell SE, Sulik KK. Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice. Alcohol May;49(3):
Zhou FC. Dissecting FASD through the global transcriptome. Alcohol Clin Exp Res Mar;39(3): doi: /acer Epub 2015 Feb 19. PubMed PMID: ; PubMed Central PMCID: PMC

14. POPULAR PRESS The Washington Post: SELF Magazine (1st mention):
SELF Magazine (follow-up piece) :  
Which was picked up by The Huffington Post: 
Harvard Gazette: 
Australian Four Corners TV program

15. Summary of Future
Currently in the 12th year of funding, and the 13th year of the grant. Fiscal year runs from June 1 to May 3
Winter of internal discussions are occurring at NIAAA regarding a new RFA for CIFASD
Spring - Summer of release of a Notice of Intent to publish an RFA (i.e. advanced warning of a RFA)
Summer of   RFA publication
Late 2016/ Early review of applications

17. Items for Consideration
Critical examination of projects as we move forward. Our current projects were never meant to be funded for life. In these times of leaner budgets, where do we get the most bang for the buck.
Path forward? Biomarkers, interventions, nutritional studies, ciliopathies, genetics, larger or more diverse samples, adults, earlier diagnosis, comorbid abuses, what?
Succession plans for projects, PIs (Administrative Core, other projects????)

18. Thank you Especially Ken, Bill, Dale, Michael, Dan, Sara Jo, John

19. Hot topics
Examination of genetic, environmental, and prenatal alcohol exposure interactions; i.e. identification of susceptibility and resistance factors
Research directed toward improving/expanding FASD diagnosis, coordinated with research translation efforts.
Globally-directed epidemiology research informed by an understanding of racial variability in presentation of symptoms.
Detailed understanding of how early ethanol exposure leads to later structural defects in the nervous system and other tissues.
Establishing methods of early detection of embryonic ethanol exposure.

20. Hot topics
Direct tests of biological, behavioral, and educational interventions for children with FASD.
Longitudinal studies of clinical status, health status, and neurocognitive functioning in children and adults with FASD.
Research focusing on the COMMON neurocognitive and behavioral abnormalities between FASD and other conditions (ADHD, learning disability, etc.) has the power to be more efficient than focusing on FASD alone.
Earlier diagnosis of affected children
Prevention of prenatally exposed pregnancies by identification of those women who are at highest-risk

21. Hot topics
Understanding the relation between parent report and real-life/real-time measurement of behavior
Understanding the relation between FASD and development of risk behaviors
3D facial combined with brain.
Measuring factors that contribute to inter-individual variability (environment, genetics)
Capitalize on birth cohorts (i.e., PASS) where we can get a better idea of QFT and lots of other in utero measures to predict how the brain develops later.

22. Current Themes - What do we need moving forward
Administrative Core
3D Facial
Nutrition and Birth Cohort
Behavior
Dysmorphology
Core
Education
Brain
Informatics Core
Developmental Projects
Basic Science