1. Enzymes Catalysis functional parts of enzymes
evaluation of enzyme activity
classification of enzymes
regulation of enzyme activity in cells
inhibitors of enzymes

2. Sucrose is very stable compound, but our enzymes can break it down quickly to generate ATP

3. Velocity acceleration rate for some enzymes

4. Mechanism of action

5. Induced fit model of enzyme action

6. Functional parts of enzyme molecule

7. The velocity of chemical reactions and Evaluation of enzyme activity

8. What is velocity?

9. Determination of velocity of enzymatic reaction

10. Velocity at different product concentraions (Michaelis-Menten curve)

11. Km for differrent enzymes

12. Linearization

13. Regulation of enzyme activity

14. Allosteric regulation

15. Feedback regulation

16. Regulation by covalent modification

17. Proteolytic attivation of enzymes

18. Dependence of enzyme activityon ph and temperature

19. pH optimum for different enzymes

20. Temperature

21. inhibitors

22. Competitive inhibitor

23. Noncompetitive inhibitor

24. Anti-HIV drugs inhibit HIV protease

25. HIV genome and protease

26. Sulfanilamides (analogs of p-aminobenzoate) for treatment of bacterial infections: inhibitors of synthesis of folic acid
Folic acid

27. Folic acid antagonists: antifolates as antitumor agents

28. Allopurinol inhibits purines breakdown and is used for treatment of gout

29. Viral infections can be treated using different thymidine analogs
AZT
Idoxuridine

30. Statins: inhibition of cholesterol biosynthesis for atherosclerosis treatment

31. Atorvastatin: powerful synthetic statin