1. Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment 
Yawu Liu, Gabriela Spulber, Kimmo K. Lehtimäki, Mervi Könönen, Ilona Hallikainen, Heidi Gröhn, Miia Kivipelto, Merja Hallikainen, Ritva Vanninen, Hilkka Soininen 
Neurobiology of Aging 
Volume 32, Issue 9, Pages (September 2011)
DOI: /j.neurobiolaging
Copyright © 2009 Elsevier Inc. Terms and Conditions

2. Fig. 1
Comparison of fractional anisotropy (FA) between AD and control groups. (A) The skeleton image (green color, FA>0.2) overlaid with the mean FA image. The yellow and red color in (B) and (C) indicate the areas having significantly decreased FA values (yellow indicates p<0.05 and red indicates p<0.01, uncorrected) along the skeleton of the fiber tracts in AD patients compared with controls. Only the areas with p<0.01 were considered to have significantly reduced FA in this study. A detail of the skeleton in the genu of corpus callosum indicates the center of fiber tracts in C and D. The pink and blue color in D indicates where the FA values were evaluated in the ROI-based analysis.
Neurobiology of Aging  , DOI: ( /j.neurobiolaging )
Copyright © 2009 Elsevier Inc. Terms and Conditions

3. Fig. 2
Region of interest of left parahippocampal tract is well back-projected to the native space of 19 controls and 17 AD patients. The last row images show the ROI in the re-sliced FA map, and T1-weighted image in axial, coronal, and sagittal planes.
Neurobiology of Aging  , DOI: ( /j.neurobiolaging )
Copyright © 2009 Elsevier Inc. Terms and Conditions

4. Fig. 3
Bland–Altman plots show that the FA values extracted from re-sliced FA skeleton and native space agree well in parahippocampal tract with a mean FA difference of 0.06 (A) and body of corpus collusam with a mean FA difference of 0.04 (B) in AD patients and controls.
Neurobiology of Aging  , DOI: ( /j.neurobiolaging )
Copyright © 2009 Elsevier Inc. Terms and Conditions

5. Fig. 4
The FA in the right parahippocampus white matter (red arrowheads) is reduced in MCI subjects and also in AD patients. The lesion locations are similar between MCI and AD patients. The second last row of images indicates where the regions of interest (ROIs) are in the ROI-based analysis. The last row of images indicates the parahippocampus white matter on T1WI images. The areas with significantly decreased FA values are marked in yellow with threshold p<0.05 and in red with threshold p<0.01.
Neurobiology of Aging  , DOI: ( /j.neurobiolaging )
Copyright © 2009 Elsevier Inc. Terms and Conditions

6. Fig. 5
In the MCI subjects, the FA of the uncinate fasciculus (red arrowheads) is significantly reduced. In AD patients, the areas with reduced FA are more extensive. The anterior arch of fornix is bilaterally affected in AD (blue arrowhead), but more severe on the right. The second last row of images indicates where the regions of interest (ROIs) are in the ROI-based analysis. The last row of images indicates the anatomical locations on T1WI images. The areas with significantly decreased FA values are marked in yellow with threshold p<0.05 and in red with threshold p<0.01.
Neurobiology of Aging  , DOI: ( /j.neurobiolaging )
Copyright © 2009 Elsevier Inc. Terms and Conditions

7. Fig. 6
The FA values of the anterior part of the body of fornix (red arrowheads) and genu of corpus callosum (blue arrowheads) are significantly decreased in AD patients. Trends for reduced FA in the two areas are also seen in the MCI subjects, but the extents of the significantly reduced AD area are less than 5mm in three orthogonal planes in MCI subjects. The second last row of images indicates where the region of interest (ROI) is in the ROI-based analysis. The last row of images indicates the anatomical locations on T1WI images. The areas with significantly decreased FA values are marked in yellow with threshold p<0.05 and in red with threshold p<0.01.
Neurobiology of Aging  , DOI: ( /j.neurobiolaging )
Copyright © 2009 Elsevier Inc. Terms and Conditions

8. Fig. 7
The FA is reduced in the superior longitudinal fasciculus (SLF) (red arrowheads) in both AD patients and MCI subjects. In AD patients, the tracts with reduced FA are more extensive compared to MCI subjects. The degeneration in the SLF shows progress. The last row of images indicates where the regions of interest (ROIs) are in the ROI-based analysis. The areas with significantly decreased FA values are marked in yellow with threshold p<0.05 and in red with threshold p<0.01.
Neurobiology of Aging  , DOI: ( /j.neurobiolaging )
Copyright © 2009 Elsevier Inc. Terms and Conditions