1. Core C – Statistics and Data Management
Wisconsin ADRC
External Advisory Committee Meeting
August 23, 2016
Rick Chappell Data Management Service Leader
Maritza Dowling DMS Co-Leader
Wisconsin Alzheimer’s Disease Research Center
University of Wisconsin
School of Medicine and Public Health
Madison VA Geriatric Research, Education and Clinical Center

2. Core C: Specific Aims – Data Management
AIM 1: Provide and maintain quality protocol and data management for projects affiliated with the Wisconsin ADRC
AIM 2: Work with the NACC to create a smooth and efficient exchange of data and to collaborate with other ADCs and AD researchers

3. Core C: Specific Aims – Statistical Collaboration
AIM 3: Create a smooth and efficient exchange of data and collaborate with other ADCs and AD researchers

4. Data Management Systems
Integrating:
Data collection
Data storage
Cataloguing
Neuroimaging data storage
Tracking and Scheduling
REGGIE
OnCore
CTMS Data
Consent Tracking
EHR Billing
REDCap
NACC Data
Panda
NeuroImage Repository
Metadata
Jira
Data Requests
Audit Trail

5. Data Management Accomplishments
Innovation
REGGIE has been moved to Dept. of Medicine to enhance local control, flexibility:
Improvements underway
Communication between different database systems
Report creation capabilities
REDCap to help track and follow other administrative functions:
Consult tracking
Simplified Data request process

6. Data Management Accomplishments
Innovation Cont.
New REDCap based statistical consultation and collaboration tracking system

7. Data Management Accomplishments
Expanded Partnerships
Coordinated UDS 3.0/REDCap implementation team
University of Kansas Medical Center, Boston University, Emory, UC-Irvine, Washington University
Subsequent work under consideration:
Standardization and sharing of data quality rules
Shared work on data export routines to NACC
Adoption Guide for other ADRC’s
Implementation Guide for moving to a paperless data entry system

8. Data Management Accomplishments
Mentoring
Provide staff training in REGGIE REDCap, and OnCore
Consultation with Neuropathology Core on LIMS software system.
Confidentiality
The REGGIE, OnCore, REDCap, JIRA and PANDA systems have configurable security and access control to address HIPPA requirements. Unique user ID’s, encryption, secure use log-in, password rules, and audit trails have been configured by the DMSC to access the database.

9. Data Management Accomplishments
Mentoring
Provide staff training in REGGIE REDCap, and OnCore
Confidentiality
The REGGIE, OnCore, REDCap, JIRA and PANDA systems have configurable security and access control to address HIPPA requirements. Unique user ID’s, encryption, secure use log-in, password rules, and audit trails have been configured by the DMSC to access the database.

10. Statistical Accomplishments
Statistical Collaboration
Interface effectively with other Cores to help achieve our overall mission.
Over twenty-five collaborative publications in the last two years in:
Clinical trials
Longitudinal data analysis
Spatial statistics
Biomarkers
Machine learning
Mentoring of students
Formalization of continuing education program

11. Statistical Accomplishments
Examples of Mentoring and Innovation
Longitudinal Analysis (Dowling): collaboration with (H. Chang, D. Tatsuoka) and Ph.D. student (S. Deng) on “Biomarker Heterogeneity and its Association with a Novel Alzheimer’s Disease Severity Factor” with a presentation at a national conference and a paper currently under review.
Integrative Data Analysis in Aging Research: An Application of New Approaches to ADNI and ROS data (Dowling): collaboration with E. Hamacker and students. paper currently under review.

12. Statistical Accomplishments
Examples of Mentoring and Innovation
Longitudinal Analyses (Chappell):
Collaboration with C. Gleason, post-doc (B. Fischer), and Stat. Ph.D. student as part of training grant rotation (R Bacher), “Neuro-mechanistic examination of gait in individuals with cognitive impairment” (submitted to J Int Neuropsych Soc).
Collaboration with L. Clark, S. Johnson, others, “Beta-amyloid and cognitive decline in late middle age: Findings from the WRAP study” (to appear in Alz & Dem).

13. Statistical Accomplishments
Examples of Mentoring (Chappell):
Co-advisor for B. Wendelberger (Committee Ph.D., for her thesis on structural connectivity modeling in functional MRI with an application to falls.
Mentoring many ADRC students and post-docs.
Local Outreach: Initiating series of formal didactic talks (3 in Fall 2016) on clinical research, joint with ICTR.
National Outreach: Initiating series (?) of workshops at ADC meetings on clinical research.

14. Future Goals
Further development and rollout of the Booked scheduling system
Further development of a statistical collaboration request system/research progress
Support and guidance for the move to a paperless data entry system.
Further mentoring and outreach.

15. Team and Collaborators
Statistics
N. Maritza Dowling
Rick Chappell
Sien Deng
Yifei Zhang
Data Management
Alice Spalitta
Charles Illingworth
DoM IT Team
A network of Clinical Collaborators and a variety of Research Subjects

16. Thank You
Questions
&
Comments