1. BEYOND THE HUMAN GENOME
Linda Phillips
When did it get personal?

2. You can now pick your date! May 12, 2011

4. 23 and me Results

6. Your Genetic Data
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Genes vs. Environment
The Delta32 version of CCR5 is inherited in a simple recessive manner. This means that someone must have two copies of Dea32 in order to have no CCR5 protein on their immune cells. Although people with two copies of Delta32 are highly resistant to the most common type of HIV, they can be vulnerable to strains of the virus that do not use CCR5 to enter immune cells. Time of progression to AIDS after infection with HIV is variable and depends on a number of factors. These factors include general immune system function, age, and exposure to other infectious diseases.

7. Who
Genotype
What It Means DD
Resistant to infection by the most common strain of HIV people usually encounter, though protection is not complete. DI
Not resistant to HIV infection but may have slower progression to AIDS after infection.
Linda Phillips II
Not resistant to HIV infection; shows average time of progression to AIDS after infection.

8. Linda Phillips does not have the APOE ε4 variant
Linda Phillips does not have the APOE ε4 variant. APOE ε4 is not the only factor contributing to Alzheimer's. People without this variant can still develop Alzheimer's Disease. Read more in the technical report.
Linda Phillips
4.9 out of 100
women of European ethnicity who share Linda Phillips's genotype will develop Alzheimer's Disease between the ages of 50 and 79.
Average
7.1 out of 100
women of European ethnicity will develop Alzheimer's Disease between the ages of 50 and 79.
What does the Odds Calculator show me?
Use the ethnicity and age range selectors above to see the estimated incidence of Alzheimer's Disease due to genetics for women with Linda Phillips's genotype. The 23andMe Odds Calculator assumes that a person is free of the condition at the lower age in the range. You can use the name selector above to see the estimated incidence of Alzheimer's Disease for the genotypes of other people in your account.
The 23andMe Odds Calculator only takes into account effects of markers with known associations that are also on our genotyping chip. Keep in mind that aside from genetics, environment and lifestyle may also contribute to one's risk for Alzheimer's Disease.
We are unable to calculate Linda Phillips's results for Alzheimer's Disease without additional analysis on 23andMe's latest platform.
The latest platform is an improved DNA chip that analyzes nearly twice as many genetic markers as the previous version. This report on Alzheimer's Disease uses genetic markers that are available only on the latest platform.
If you want this analysis performed, please upgrade your profile.
Please keep in mind that:
This report on Alzheimer's Disease includes information about the APOE ε4 variant that is associated with substantially higher risk for Alzheimer's.
Estimates of Alzheimer's risk due to the APOE ε4 variant presented in this report are established in European populations only. More research is needed to establish the variant's effect in non-European populations.
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22. Planaria Regeneration Lab

23. Planaria Regeneration Lab
Planaria are a type of flatworm belonging to the phylum Platyhelminthes. With their rudimentary eyes, brain, gut, gonads, yet no circulatory or respiratory systems; they are one of the simplest types of multicellular animals.
For over 100 years, scientists have known that planaria can regenerate. Their amazing regenerative capacities are due to the large number of stem cells that they contain, called neoblasts. Around the turn of the century the famous geneticists, Thomas Hunt Morgan, discovered that a fraction of the worm, just 0.3%, can regenerate a whole new animal. In this experiment we will investigate the planaria’s remarkable regenerative abilities.

24. β – Globin Gene Activity

25. DNA Chips

27. Simulation – Using Microarray to Study Gene Expression in Normal and Cancer Cells

28. cDNA Activity

31. Special Thanks to Amgen Canada

32. Very Special Thanks to my students for allowing me to use their images and work!
Please see references file for a complete list of references and suggested reading.