1. Assist. Prof. Dr. Açelya Yılmazer Aktuna
Cell Biology
BME140
Lecture 9
Cell Cycle
Assist. Prof. Dr. Açelya Yılmazer Aktuna

2. CELL CYCLE Signal transduction Change in gene expression
Steps in cell cycle:
Signal transduction
Change in gene expression
Activation of Cyclin/CDK complexes (START)
Phosphorylation of pocket proteins (E2F)
DNA replication

3. CELL CYCLE Passing S phase checkpoints Increase in cell size (G2)
Steps in cell cycle:
Passing S phase checkpoints
Increase in cell size (G2)
Entry to M phase
Chromosome alignment during M phase
Cytokinesis

4. APOPTOSIS & NECROSIS
Cells Die in Two Different Ways: Necrosis and Apoptosis
Apoptosis Is Induced via at Least Two Different Pathways