1. Critical Reviews in Oncology / Hematology
Radiotherapy in the age of cancer immunology: Current concepts and future developments 
Mauro Loi, Isacco Desideri, Daniela Greto, Monica Mangoni, Mariangela Sottili, Icro Meattini, Carlotta Becherini, Francesca Terziani, Camilla Delli Paoli, Emanuela Olmetto, Pierluigi Bonomo, Lorenzo Livi 
Critical Reviews in Oncology / Hematology 
Volume 112, Pages 1-10 (April 2017)
DOI: /j.critrevonc
Copyright © 2017 Elsevier B.V. Terms and Conditions

2. Fig. 1
Cancer Immunoediting theory. (A) ELIMINATION: aberrant antigene-expressing cancer cells are detected and attacked by the host immune system (B) EQUILIBRIUM: emergence of clones resistant to immune rejection (C) ESCAPE: tumor cells thwart immune response due to poor antigene expression and recruitment of immunosuppressive cells.
Critical Reviews in Oncology / Hematology  , 1-10DOI: ( /j.critrevonc )
Copyright © 2017 Elsevier B.V. Terms and Conditions

3. Fig. 2
Effects of radiation on cancer immune environment. (A) Immunogenic Cell Death: release of chemical byproducts of radiation-induced cell death thrive anti-tumor immune response through stimulation of antigene processing and lymphocyte priming (B) Vascular modifications allows recruitment of immune infiltration from the bloodstream (C) Exposure to radiation induce expression of major histocompatibility complex (MHC) I on cancer cells surface, that facilitate immune recognition.
Critical Reviews in Oncology / Hematology  , 1-10DOI: ( /j.critrevonc )
Copyright © 2017 Elsevier B.V. Terms and Conditions

4. Fig. 3
Strategies to obtain immunity-enhanced radiotherapy (A) Antigene-based cancer vaccines (B) Targeting intracellular signalization pathways involved in immune response modulation (C) Targeting resident intratumoral population of immunosuppressive cells (M2 macrophages, T-regulator lymphocytes, Myeloid-derived stem cells). (D) Immune check point inhibition (E) Altered fractionations and heavy particles therapy.
Critical Reviews in Oncology / Hematology  , 1-10DOI: ( /j.critrevonc )
Copyright © 2017 Elsevier B.V. Terms and Conditions