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Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass- spectrometry in type 2 diabetes to assess polyol pathway activity 

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Presentation on theme: "Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass- spectrometry in type 2 diabetes to assess polyol pathway activity "— Presentation transcript:

1 Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass- spectrometry in type 2 diabetes to assess polyol pathway activity  Hidenori Yoshii, Hiroshi Uchino, Chie Ohmura, Kenji Watanabe, Yasushi Tanaka, Ryuzo Kawamori  Diabetes Research and Clinical Practice  Volume 51, Issue 2, Pages (February 2001) DOI: /S (00)

2 Fig. 1 Urinary excretion of myo-inositol, sorbitol, fructose in diabetic and healthy controls. *P<0.05, P values are for diabetic subjects (■) versus healthy control (□). Data are mean±S.E. Diabetes Research and Clinical Practice  , DOI: ( /S (00) )

3 Fig. 2 Fasting blood glucose level (FBS), urinary excretion of glucose and myo-inositol in diabetic subjects during the course of improvement of glycemic control. A weekly changes of FBS (top), urinary glucose excretion (middle) and urinary myo-inositol excretion (lower) between Group A (–○–) and Group B (–•–). However glucosuria ceased in both groups, Group A showed simultaneous normalization of urinary excretion of myo-inositol (<50 mg/day) with the disappearance of glucosuria, while Group B showed delayed normalization of urinary myo-inositol. P values are for Group A vs Group B. *P<0.05 Data are mean±S.E. Diabetes Research and Clinical Practice  , DOI: ( /S (00) )

4 Fig. 3 Relationship between the amounts of 24 h urinary myo-inositol excretion on the day when glucosuria ceased and the amounts of 24 h urinary glucose at one week before the disappearance of glucosuria (r=0.42, P<0.05). Diabetes Research and Clinical Practice  , DOI: ( /S (00) )

5 Fig. 4 The amounts of 24 h urinary myo-inositol, sorbitol and fructose in the patients in Group A and Group B on the day when glucosuria ceased. The patients in Group B had significantly higher amounts of urinary excretion for myo-inositol, sorbitol and fructose just in glucosuria was disappeared. P values are for Group A vs Group B. P<0.05 Data are mean±S.E. Diabetes Research and Clinical Practice  , DOI: ( /S (00) )


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