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A Susceptibility Locus for Migraine with Aura, on Chromosome 4q24
Maija Wessman, Mikko Kallela, Mari A. Kaunisto, Pia Marttila, Eric Sobel, Jaana Hartiala, Greg Oswell, Suzanne M. Leal, Jeanette C. Papp, Eija Hämäläinen, Petra Broas, Geoffrey Joslyn, Iiris Hovatta, Tero Hiekkalinna, Jaakko Kaprio, Jürg Ott, Rita M. Cantor, John- Anker Zwart, Matti Ilmavirta, Hannele Havanka, Markus Färkkilä, Leena Peltonen, Aarno Palotie The American Journal of Human Genetics Volume 70, Issue 3, Pages (March 2002) DOI: /339078 Copyright © 2002 The American Society of Human Genetics Terms and Conditions
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Figure 1 Two-point parametric linkage analyses (dominant model allowing for heterogeneity) for the 350-marker genomewide screen of 50 families with migraine. Blackened squares denote the two-point LOD scores when only individuals suffering from MA were considered to be affected; unblackened diamonds denote the two-point LOD scores for a broader phenotype, in which both individuals with MA and individuals with MO were considered to be affected. Analyses were performed by the LINKAGE program, as described in the text. The American Journal of Human Genetics , DOI: ( /339078) Copyright © 2002 The American Society of Human Genetics Terms and Conditions
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Figure 2 Multipoint parametric and nonparametric linkage analyses of 4q, with markers D4S2409 (96 cM), D4S2380 (101 cM), D4S1647 (105 cM), and D4S3240 (114 cM). Analyses were performed by the GENEHUNTER program, as described in the text. The vertical axis presents both the parametric (i.e., HLOD [unbroken line]) and nonparametric (i.e., NPLall [dotted line]) values along a 20-cM region of chromosome 4. The American Journal of Human Genetics , DOI: ( /339078) Copyright © 2002 The American Society of Human Genetics Terms and Conditions
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