1. A Conversation on Risk Management in Environmental Monitoring and Public Health Labs
Andrew W. Nelson, PhD, MPH

2. Innovative Solutions for Countering Biological and Chemical Threats Globally
Our Mission: Strengthen capacities to safely, securely, and responsibly detect, handle, and control dangerous biological and chemical agents
Abandoned Bhopal Plant
Photo credit: AP/Saurabh Das

3. IBCTR’s Global Experience

4. IBCTR Core Capabilities
Human Capacity Development
Risk Management
Analysis
Health Security
Human Capacity Development
Safety and security risk management training
Establishing local training centers and trainers
Law enforcement specific training
Risk Management
Risk management standards and regulatory frameworks
Core risk management program documents
Lab design / programming expertise
Facility specific safety and security threat, vulnerability, and risk assessments
Safety and security upgrades
Analysis
Global, regional, country analyses of bio and chem sectors
Network analyses of laboratory systems
Disease outbreak modeling
Health Security
Surveillance and control
Public and vet health
Incident detection and response

5. IBCTR Core Capabilities
Human Capacity Development
Risk Management
Analysis
Health Security
Human Capacity Development
Safety and security risk management training
Establishing local training centers and trainers
Law enforcement specific training
Risk Management
Risk management standards and regulatory frameworks
Core risk management program documents
Lab design / programming expertise
Facility specific safety and security threat, vulnerability, and risk assessments
Safety and security upgrades
Analysis
Global, regional, country analyses of bio and chem sectors
Network analyses of laboratory systems
Disease outbreak modeling
Health Security
Surveillance and control
Public and vet health
Incident detection and response

6. Jordan University of Science & Technology Biorisk Management Training Center
Objective: Create an internationally recognized training center
Develop Business Plan with JUST
Develop JUST trainers and a sustainable trainer development plan
Renovate an existing building to illustrate best practices and serve as a training facility

7. Global Biorisk Management Curriculum (GBRMC)
Biosafety and Biosecurity training materials
Strategic, sustainable
Customizable
Network of trainers
In over 61 countries
861 trainers in the network

8. Chemical Safety and Security Training
What do we train?
Chemical Safety and Security
Who do we train?
Academic chemists
Chemical engineers
Chemical industries professionals
Photo credit for all photos: William Morgan Alley

9. Types of Chemical Security Training
Chemical Safety and Security Officers
Policy and Legislation Workshops
Chemical Supply Chain Security
Risk Assessment
Emergency preparedness
Chemical Material Control and Accountability
Tailored training for Visiting Scholars
Photo credit for all photos: William Morgan Alley

10. First Responder Training and Field Biosecurity
Provide BRM Training to First Responders and Field Biosecurity Workers
Who Do We Train?
First Responders
Law Enforcement
Military
Field epidemiologists and clinicians
What Do We Train?
Field Biosecurity and Operations
Site Safety to include PPE selection and use
Field sampling and sample transport
Decontamination and waste management
Site and event management
Photo credit for all photos: William Morgan Alley

11. IBCTR Core Capabilities
Human Capacity Development
Risk Management
Analysis
Health Security
Human Capacity Development
Safety and security risk management training
Establishing local training centers and trainers
Law enforcement specific training
Risk Management
Risk management standards and regulatory frameworks
Core risk management program documents
Lab design / programming expertise
Facility specific safety and security threat, vulnerability, and risk assessments
Safety and security upgrades
Analysis
Global, regional, country analyses of bio and chem sectors
Network analyses of laboratory systems
Disease outbreak modeling
Health Security
Surveillance and control
Public and vet health
Incident detection and response

12. Advancing Biological Risk Management Standards
Help develop global standards for laboratory biorisk management
CWA 15793: Laboratory Biorisk Management
ISO standard (ISO/WD 35001)
CWA 16393: Guidelines for the implementation of CWA 15793
CWA 16335: Competence of a Biosafety Professional

13. IBCTR’s Risk Assessment Methodologies
Vision
Create standardized approaches to safety and security risk assessment
Create a tool for risk prioritization and communication
The Tools
Biosafety RAM
Biosecurity RAM
Chem SAM
Chem-SAM

14. Tools for Risk Management
Library of Core Documents for Risk Management
Biorisk Management Manual template
Operations and Maintenance Manual template
SOP templates
Library of Core Documents for risk management
Biorisk Management Manual template
Operations and Maintenance Manual template
SOP templates including
Autoclaves
Biosafety Cabinet
Personal Protective Equipment
Spill Response
Biological Waste Handling
Inventory Management
Chemical Hygiene Plan

15. Tools for Risk Management
Chemical Inventory Management Software
Promote chemical management in the laboratory
Enhance safety and security
Hands-on training
Sandia developed CMS inventory tool
Chemical Inventory Management Software
Promote a fundamental approach to managing chemicals in the laboratory, focused on security and safety
Hands-on training on effective chemical inventory management systems
Including: laboratory management best practices for procurement, receiving, tracking, and proper storage of chemicals
Sandia developed CIMS Excel-based inventory tool
Designed to be used as a simple CIMS system at small institutions

16. Security Upgrades
Reduce the theft risk of valuable/dangerous biological or chemical materials

17. Laboratory and Facility Design
Laboratory Best Practices for Intrinsic Safety and Security
The pictures are from the BOD for the new FMD diagnostic facility in Kenya that was designed using the prototype concept and provided to DTRA and the general contractor to generate construction ready drawings.
Couldn’t find the right place, but would also be important to note that we coordinate design charrette meetings and provide design review to ensure safety and security best practices are taken into consideration during the design process.

18. Authoring Key Risk Management Texts
Laboratory Biorisk Management (2015)
Laboratory Biosecurity (2007, 2nd ed. in preparation)
Both books focus on
Rigorous risk assessment
Deciding how to mitigate those risks deemed to be unacceptable
Establishing mechanisms to constantly evaluate the effectiveness of the control measures

19. IBCTR Core Capabilities
Human Capacity Development
Risk Management
Analysis
Health Security
Human Capacity Development
Safety and security risk management training
Establishing local training centers and trainers
Law enforcement specific training
Risk Management
Risk management standards and regulatory frameworks
Core risk management program documents
Lab design / programming expertise
Facility specific safety and security threat, vulnerability, and risk assessments
Safety and security upgrades
Analysis
Global, regional, country analyses of bio and chem sectors
Network analyses of laboratory systems
Disease outbreak modeling
Health Security
Surveillance and control
Public and vet health
Incident detection and response

20. Lab Network Analysis Objective: Activities: Connect laboratories
Reduce sample transport time
Inform lab network strategies
Activities:
Identify and develop transportation networks
Develop laboratory network plans
Sample transportation network analysis
Ebola response
Outcomes:
Enhance capacity to detect and attribute outbreaks of infectious disease
Improve threat identification and notification
Process improvements to facilitate increased test throughput by systems optimization
Decrease sample turn around time through increased efficiency in the system
Reduce proliferation of laboratories by enabling better connections
Increase potential that investments are sustainable
Provides evidence-based information to inform policy decisions
Support the development and improvement of safe and secure sample transportation system

21. Development of Biological and Chemical Analyses and Tools
Unmanned Aircraft Systems (UAS) Sample Transport
Objective: determine feasibility of UAS to transport biological specimens
Considerations:
Technical capabilities of UAS
Advantages and disadvantages of various sample transport modes
Case analysis:
Ebola samples in Lofa, Liberia

22. IBCTR Core Capabilities
Human Capacity Development
Risk Management
Analysis
Health Security
Human Capacity Development
Safety and security risk management training
Establishing local training centers and trainers
Law enforcement specific training
Risk Management
Risk management standards and regulatory frameworks
Core risk management program documents
Lab design / programming expertise
Facility specific safety and security threat, vulnerability, and risk assessments
Safety and security upgrades
Analysis
Global, regional, country analyses of bio and chem sectors
Network analyses of laboratory systems
Disease outbreak modeling
Health Security
Surveillance and control
Public and vet health
Incident detection and response

23. Veterinary Capacity Building
Veterinary professionals are on the forefront of infectious disease outbreaks
Therefore, we focus on:
Developing policies to control infectious diseases
Creating a stronger clinical sector
Building local capacity to confirm infectious disease outbreaks
WHY: Veterinary professionals are on the forefront of infectious disease outbreaks:
60% of human pathogens are zoonotic
80% of animal pathogens are multi-host
75% of emerging diseases are zoonotic
80% of potential bioterrorism agents are zoonotic pathogens
NEEDS: Building veterinary capacity at the sector level
Governmental sectors must establish policy to detect, monitor and prevent infectious diseases
Public and private clinical veterinarians serve as detectors, and must be trained to detect, monitor, and collect samples to test for infectious diseases
Laboratories must have the capacity to analyze infectious samples and prevent accidental or intentional release into the environment
WHAT WE DO
Developing policies to control infectious diseases
Working group meeting to revise or establish infectious disease control policies and procedures
Create pilot project to enforce practices
Creating a stronger clinical sector
Clinical veterinarians are trained to detect clinical symptoms of infectious diseases, collect the most appropriate sample for laboratory submission, and to establish preventative programs
Building indigenous capacity to confirm infectious disease outbreaks
Implementation of molecular biology if resources are in place to sustain the effort
Provision of pathology and histopathology capabilities to augment existing methods and reduce the reliance on isolation and culture
Establishing a culture of safety and security

24. Mekong Delta Exercise (TTX Example)
Objective: Evaluate Cross-Sector, Cross-Border One Health Preparedness
Strategic / Policy Level based on existing preparedness plans
Emerging, unknown zoonotic outbreak scenario
Participants
Cambodia, Lao PDR, Vietnam, Thailand and Myanmar
Ministries of Health, Agriculture, Environment and Foreign Affairs
External evaluators: AFRIMS, NAMRU-2, US Embassy, CDC
Results
Participant-driven After Action Report
Participant-created local working groups
Photo credit: William Morgan Alley

25. Fighting Ebola Improve biosafety and biosecurity
Technical assistance for labs with suspected Ebola samples
Model national infrastructure
Reduce sample transport time
inform lab placement

26. SNL Conclusions Sandia is a US Government National Security Laboratory
Federally Funded Research and Development Center (FFRDC) status
Mission to provide technical advice and support on national security issues to USG
Sponsors can tap into the entirety of Sandia, such as:
Security specialists
Systems analysis
Chem and bio detection, bioinformatics, bioforensics, environmental restoration
International nuclear nonproliferation experience
IBCTR has 12+ years of global collaborative bio and chem threat reduction experience
Multi-disciplinary team
OIE Collaborating Centre for Laboratory Biorisk Management
SNL has infrastructure for international engagement
International business services
International programs building, including training, technology, and demonstrations area
Demonstrated ability to work in diverse business environments
Host visiting scholars at Sandia and/or meet in 3rd party countries to advance projects
Extensive global travel experience

27. Key Partners in Addressing the Biosecurity Threat

28. How can we work together? Let’s continue to discuss:
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