1. NAMED REACTIONS

2. A reaction which is based on scientist name or product name is called as NAMED REACTION.
A reagent which is based on scientist name or product name is called as NAMED REAGENT.

3. FAMILIAR NAMED REACTIONS:
SOME OF THE IMPORTANT NAMED REACTIONS
1. BECKMANN’S REARRANGEMENT
2.FRIES REARRANGEMENT
3. SCHIMDT’S REARRANGEMENT
4.OPPENAUIRE’S OXIDATION
5.CLEMMENSEN’S REDUCTION
6.MANNICH REACTION
7.PHILLIPS REACTION

4. BECKMANN’S REARRANGEMENT
Def: A rearrangement reaction in which conversion of keto oxine into N-substituted amide in presence of SULPHURIC ACID is called as beckmann’s rearrangement. CATALYST: Conc.H2SO4 ,PCl 5 , PCl 3

5. GENERAL MECHANISM

6. APPLICATIONS: 1. Determines the configuration of keto- oximes 2
APPLICATIONS: 1. Determines the configuration of keto- oximes 2.Synthesis of caprolactom from cyclohexanoxime 3.Synthesis of Isoquinoline from Cinnamaldoxime

7. FRIES REARRANGEMENT
Def: A rearrangement reaction in which Aromatic Ester undergo reaction converts to Aromatic ketone in presence of ALLUMINIUM CHLORIDE. CATALYST: Anhydrous alluminium chloride

8. GENERAL REACTION

9. Applications:
1.Synthesis of Adrenaline
2.Synthesis of catachol esters

10. SCHIMDT’s REARRANGEMENT
Def: when a carboxylic acid undergo reaction with Hydraloicacid in the presence of conc sulphuricacid gives corresponding Amine is called schimdth rearrangement. CATALYST: Sulphuricacid

11. GENERAL REACTION

12. Applications:
1.preparation of Amines
2.synthesis of L-amino acid

13. OPPENAUER’S OXIDATION
Def: when a secondary alcohol undergo reflexation with a Ketone in the presence of Alluminium tertiory butoxide on oxidation results formation of ketone along with secondary alcohol. Catalyst: Aluminium tertiory butaoxide.

14. GENERAL MECHANISM

15. Applications: 1. Synthesis of 6 methyl 3,5,7-octatriene-2-one 2
Applications: 1.Synthesis of 6 methyl 3,5,7-octatriene-2-one 2.Synthesis of L- decanone 3.Synthesis of cholesterol

16. CLEMMENSEN’S REDUCTION
Def: when a carbonyl compounds undergo reduction in the presence of zinc amalgum in conc.HCl gives corresponding hydrocarbons as active methylene group compound. Catalyst: Conc.zn-Hg/Hcl

17. GENERAL MECHANISM

18. Applications: 1. Reduction of aromatic & aliphatic carbonyl compounds
2.Reduction of keto acids
3.Reduction of phenolic carbonyl compounds

19. MANNICH REACTION
Def: condensation reaction which involves the ketone reaction with formaldehyde and primary or secondary amine to give mannich base is called mannich reaction. Catalyst: No catalyst

20. GENERAL REACTION

21. APPLICATIONS: 1. synthesis of Cocaine 2.synthesis of Tutocaine

22. PHILLIPS REACTION
Def: when orthophynylene diamine undergo reaction with carboxylic acid in the presence of base it undergo cyclisation and form benzimidazole as product. Catalyst: 10% of NaOH

23. GENERAL MECHANISM:

24. Applications:
1.Philips reaction is generally used for synthesis of heterocyclic compounds
2.Ortho phenylene diamine undero reaction which acetic acid to aceto benzimidazole

25. Thank you