1. The Role of Computer-aided Detection and Diagnosis System in the Differential Diagnosis of Thyroid Lesions in Ultrasonography 
Tien-Chun Chang 
Journal of Medical Ultrasound 
Volume 23, Issue 4, Pages (December 2015)
DOI: /j.jmu
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2. Figure 1
(A) Locate the first point in the left border of the thyroid lesion with the largest diameter. (B) Draw to extend across to the right border with the largest diameter of the lesion. Locate the second point of the middle part in the upper border of the thyroid nodule, then draw to the middle part in the lower border of the thyroid nodule.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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3. Figure 2
For the longitudinal axis, locate the second point at the middle part in the upper border of the thyroid nodule, then draw to the middle part in the lower border of the thyroid nodule.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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4. Figure 3
As soon as the two axes are defined, the contour is automatically generated by the computer-aided detection and diagnosis system.
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5. Figure 4
Users can choose to fine-tune the contour by adding an additional marker, followed by clicking and dragging it.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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6. Figure 5
The thyroid lesion is<1 cm in diameter; fine-needle aspiration cytology needs to be performed.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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7. Figure 6
The thyroid lesion from Figure 5. Parameter 1 (microcalcification) and Parameter 2 (hypoechogenicity) detected by the computer-aided detection and diagnosis system are both positive.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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8. Figure 7
The thyroid lesion is<1 cm in diameter; follow-up only is required.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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9. Figure 8
The thyroid lesion from Figure 7. Parameter 1 (microcalcification) and Parameter 2 (hypoechogenicity) detected by the computer-aided detection and diagnosis system are both negative.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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10. Figure 9
Thyroid lesions 1–1.5 cm in diameter, for which fine-needle aspiration cytology needs to be performed.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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11. Figure 10
The thyroid lesion from Figure 9. Either Parameter 1 (microcalcification) or Parameter 2 (hypoechogenicity) detected by the computer-aided detection and diagnosis system is positive.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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12. Figure 11
Thyroid lesions 1–1.5 cm in diameter which need follow-up only.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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13. Figure 12
Thyroid lesion from Figure 11. Both Parameter 1 (microcalcification) and Parameter 2 (hypoechogenicity) detected by the computer-aided detection and diagnosis system are negative.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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14. Figure 13
The thyroid lesion is>1.5 cm in diameter, which needs fine-needle aspiration cytology.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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15. Figure 14
Thyroid lesion from Figure 13. The presence of any one of Parameters 1–4 (microcalcification, hypoechogenicity, heterogenicity, and blurred margin) detected by the computer-aided detection and diagnosis system.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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16. Figure 15
Thyroid lesions>1.5 cm in diameter, which need follow-up only.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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17. Figure 16
Thyroid lesion from Figure 15. Parameters 1–4, detected by the computer-aided detection and diagnosis system, are all negative.
Journal of Medical Ultrasound  , DOI: ( /j.jmu )
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