1. Using Drug Ontology to Bridge Clinical Trial Eligibility and Patient Record
Helen Chen
July 1, 2008

2. Drug Class Information in CT #8
monotherapy with metformin, insulin secretagogue, or alpha-glucosidase inhibitors and a low dose combination of all
Long term insulin therapy
Therapy with rosiglitazone (Avandia) or pioglitazone (Actos), or extendin-4 (Byetta), alone or in combination
corticosteroids
weightloss drugs e.g., Xenical (orlistat), Meridia (sibutramine), Acutrim (phenylpropanol-amine), or similar medications
nonsteroidal anti-inflammatory drugs
Use of warfarin (Coumadin), clopidogrel (Plavix) or other anticoagulants
Use of probenecid (Benemid, Probalan), sulfinpyrazone (Anturane) or other uricosuric agents

3. Prescription Information in Patient Database
NDC Code
"132139","131933"," ","GlipiZIDE-Metformin HCl MG Tablet"," ",98630," ","TABS","","MG "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl MG Tablet"
"132152","131946"," ","GlipiZIDE-Metformin HCl MG Tablet"," ",98629," ","TABS","","MG "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl MG Tablet"
"132407","132201"," ","GlipiZIDE-Metformin HCl MG Tablet"," ",98628," ","TABS","","MG "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl MG Tablet"
"132642","132436","C ","GlipiZIDE-Metformin HCl TABS"," ",98630,"","TABS",""," "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl TABS"

4. Drug Ontology By Samson et al
project seeks to discover new therapeutic uses and adverse effects of drugs by finding diseases that have gene expression profiles similar to those of the known indications and adverse effects of drugs

5. Drug Ontology By Samson et al – quoted from drug ontology documentation

6. Mapping Needed Between CT and Patient Record
Drug Ontology CT
MechanismOfAction C
metformin, C C
insulin secretagogue
GeneralDrugType
nonsteroidal anti-inflammatory
drugBank: DB00331
RxNORM: 6809
alpha-glucosidase inhibitors C
anticoagulants
uricosuric agents
NDC: : GlipiZIDE-Metformin HCl MG Tablet
NDC: : GlipiZIDE-Metformin HCl MG Tablet
NDC: :GlipiZIDE-Metformin HCl TABS