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Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies  Maurizio Ricci, Carmelo Puglia,

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Presentation on theme: "Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies  Maurizio Ricci, Carmelo Puglia,"— Presentation transcript:

1 Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies  Maurizio Ricci, Carmelo Puglia, Francesco Bonina, Caterina Di Giovanni, Stefano Giovagnoli, Carlo Rossi  Journal of Pharmaceutical Sciences  Volume 94, Issue 5, Pages (May 2005) DOI: /jps.20335 Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

2 Figure 1 PCS analysis of the IND loaded NLC.
Journal of Pharmaceutical Sciences  , DOI: ( /jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

3 Figure 2 OPC analysis of IND loaded NLC expressed as population number versus particle size. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

4 Figure 3 SEM picture of freshly prepared IND loaded NLC.
Journal of Pharmaceutical Sciences  , DOI: ( /jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

5 Figure 4 Permeation profiles of indomethacin through SCE membranes from different gel formulations (A–D). (⧫) formulation A; (▪) formulation B; (▴) formulation C; (●) formulation D. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

6 Figure 5 Percentage inhibitions (PIE) of UVB-induced erythema by different topical formulations (gel A–D) containing IND (2%). Data represent the mean for ten subjects. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

7 Figure 6 Total stratum corneum weight obtained after 20 tape-stripping effected t=1, 3, and 6h from the removal of A–C formulations. Data represent the mean for 10 subjects. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

8 Figure 7 Total amount of IND within the tape-stripped stratum corneum after t=1, 3, and 6h from the removal of A–C formulations. Data represent the mean for ten subjects. ND, not detectable. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

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