1. High-density impedance spectroscope for single cell analysis
2016 ECE Special Seminar
High-density impedance spectroscope for single cell analysis
Speaker: Jaehoon Chung
(Institute of Microelectronics in Singapore)
There has been escalating market needs for miniaturized biosensors that measure biological substances accurately and reliably. In parallel, these biosensors are required to provide high sensitivity, high target-specificity, and portability in a low price. Leveraging the recent advances in electronic industry, attention to complementary metal-oxide-semiconductor(CMOS) has been increasing towards biomedical applications, because CMOS integrated circuits (ICs) with sensing elements can precisely interpret physical/chemical quantities from biological samples to electrical signals in a rapid, versatile, small foot-print and cost-effective way as integrated biosensors.
In this presentation, a sensitive label-free CMOS-based high-density micro-array sensor is mainly presented. The sensor array measures electrical impedance signals from tumor cells, which offers a direct identification and enumeration of target cells, obviating the need of bulky, skill-intensive and expensive optical microscopy. Rapid and automated tumor-cell detection was demonstrated using MCF-7 breast cancer cells, by impedance measurement of the cells on microelectrode array. The electrical impedance spectroscopy (EIS) quantifies loaded cells rapidly (< 2 minutes) in a single cell resolution, with > 95% of mapping accuracy compared to the one obtained from an optical microscope.
Biography
Jaehoon Chung received his B.S. and M.S. in electrical engineering from Korea University in Korea in 1996 and 1998, respectively. In 2009 he received his Ph.D. in electrical engineering at University of Minnesota – twin cities. Prior to his Ph.D. study, he served as a research scientist at LG Electronics. For his post-doctoral work, he served as a research fellow at Massachusetts General Hospital and Harvard Medical School.
He is currently a head of department of bioelectronics program at Institute of
Microelectronics in Singapore. His main research interest is the miniaturized biomedical devices for clinical translation of biomedical devices, combining advances in microfluidics, electronics and nanotechnology.
Time: (Tue) 4:30 pm
Location: EB1, E207