1. Volume 20, Issue 1, Pages 90-98 (January 2013)
In Vivo Endoluminal Ultrasound Biomicroscopic Imaging in a Mouse Model of Colorectal Cancer 
Kelly Z. Alves, DSc, Rossana C. Soletti, PhD, Marcelo A.P. de Britto, MD, MSc, Dyanna G. de Matos, BS, Mônica Soldan, MD, DSc, Helena L. Borges, PhD, João C. Machado, PhD 
Academic Radiology 
Volume 20, Issue 1, Pages (January 2013)
DOI: /j.acra
Copyright © 2013 AUR Terms and Conditions

2. Figure 1
Cross-sectional view of the endoscope tip containing the ultrasonic (US) miniprobe (US transducer and the catheter) inserted into the accessory channel of a pediatric flexible bronchofiberscope. The light channel and the objective lens are also seen.
Academic Radiology  , 90-98DOI: ( /j.acra )
Copyright © 2013 AUR Terms and Conditions

3. Figure 2
Endoluminal ultrasound biomicroscopic (eUBM) (left) and colonoscopic (center) images obtained simultaneously in vivo from a healthy portion of a mouse colon and the corresponding hematoxylin and eosin–stained histologic section (right) (40 × magnification). The eUBM image displays the ultrasound catheter miniprobe (Mp) at the center of the lumen and moving away from the miniprobe the hyperechoic mucosa (Mu) layer, a second hypoechoic layer corresponding to the muscularis mucosae (Mm), and a third hyperechoic layer, submucosa (Sm), followed by the forth hypoechoic muscularis externa (Me) layer. The endoscopic image reveals a clean lumen and the miniprobe tip at the top. The layers identified in the ultrasound image are well correlated with histology.
Academic Radiology  , 90-98DOI: ( /j.acra )
Copyright © 2013 AUR Terms and Conditions

4. Figure 3
Endoluminal ultrasound biomicroscopic (eUBM) image (left) obtained in vivo and the corresponding hematoxylin and eosin–stained histologic section (right) (40 × magnification) of a mouse colon containing a lymphoid hyperplasia in the colonic wall. The eUBM image displays the ultrasound catheter miniprobe (Mp), the hyperechoic mucosa (Mu) layer, a hypoechoic layer corresponding to the muscularis mucosae (Mm), the hyperechoic submucosa layer (Sm), and a hypoechoic lymphoid hyperplasia (Lh) lesion. Both colonic layers and the lymphoid hyperplasia are clearly seen on the histologic image, which includes the muscularis externa (Me) layer.
Academic Radiology  , 90-98DOI: ( /j.acra )
Copyright © 2013 AUR Terms and Conditions

5. Figure 4
Endoluminal ultrasound biomicroscopic (eUBM) (left) and colonoscopic (center) images obtained simultaneously in vivo from a mouse colon containing a tumor (Tu) and the corresponding hematoxylin and eosin–stained histologic section (right) (40 × magnification). The endoscopic image reveals a large protruded lesion. The eUBM image displays the ultrasound catheter miniprobe (Mp) at the center of the lumen and the hyperechoic mucosa (Mu) and hypoechoic muscularis externa (Me) layers. The tumor boundaries are outlined at the endoscopic image, and the miniprobe tip is at the bottom. The tumor identified in the eUBM image is well correlated with the histologic image.
Academic Radiology  , 90-98DOI: ( /j.acra )
Copyright © 2013 AUR Terms and Conditions

6. Figure 5
Endoluminal ultrasound biomicroscopic (eUBM) (left) and colonoscopic (center) images obtained simultaneously in vivo from a mouse colon containing two synchronic tumors (Tu) and the corresponding hematoxylin and eosin–stained histologic section (right) (40 × magnification). The eUBM image displays the ultrasound catheter miniprobe (Mp) at the center of the lumen and the hyperechoic mucosa layer (Mu). The endoscopic image reveals the two synchronic protruded tumors with outlined boundaries and the miniprobe tip at the top. The two tumors are seen on the histologic examination from the same colonic site.
Academic Radiology  , 90-98DOI: ( /j.acra )
Copyright © 2013 AUR Terms and Conditions

7. Figure 6
Endoluminal ultrasound biomicroscopic (eUBM) image (left) obtained in vivo and the corresponding hematoxylin and eosin–stained histologic section (right) (40 × magnification) of a mouse colon containing a mucosal thickened area. The eUBM image displays the ultrasound catheter miniprobe (Mp), the hyperechoic mucosa layer (Mu), a hypoechoic layer corresponding to the muscularis mucosae (Mm), and the hypoechoic muscularis externa (Me) layer. Both colonic layers and the mucosal thickness are clearly seen on the histologic image.
Academic Radiology  , 90-98DOI: ( /j.acra )
Copyright © 2013 AUR Terms and Conditions