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Degradation. At the postsynaptic neuron tropolone inhibits the enzyme catechol-O-methyltransferase (COMT), which inactivates norepinephrine (6a). Normetanephrine.

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Presentation on theme: "Degradation. At the postsynaptic neuron tropolone inhibits the enzyme catechol-O-methyltransferase (COMT), which inactivates norepinephrine (6a). Normetanephrine."— Presentation transcript:

1 Degradation. At the postsynaptic neuron tropolone inhibits the enzyme catechol-O-methyltransferase (COMT), which inactivates norepinephrine (6a). Normetanephrine (NM) is formed by the action of COMT on norepinephrine. At the presynaptic neuron degradation by monoamine oxidase (MAO) is blocked by the monoamine oxidase inhibitors phenelzine and tranylcypromine (6b), as described in Figure 63–5. Source: Disorders of Mood and Anxiety, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: Accessed: October 10, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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