1. Human rabies virus immune globulin
Drugbank ID : DB11603

2. Description : Indication : Pharmacodynamics : NA
It is indicated for individuals suspected of exposure to rabies, particularly severe exposure, with one exception: persons who have been previously immunized with HDCV Rabies Vaccine in a pre-exposure or postexposure treatment series should receive only vaccine.
Pharmacodynamics :

3. Mechanism of action :
It provides passive protection by neutralizing the rabies virus when given to individuals exposed to rabies virus. When a rabies immune globulin dose of 20 IU/kg was given simultaneously with the first dose of rabies vaccine, levels of passive anti-rabies antibody were detected 24 hours after injection in all individuals. There was minimal or no interference with the immune response to the initial and subsequent doses of rabies vaccine, including booster doses.

4. Targets : Affected organisms : Categories : Sequence: NA
Humans and other mammals
Categories :
Sequence:

5. Brands : Hyperab Rabies Immune Globulin Human
Company : Cutter Med & Biol, Division Of Miles Canada Ltd.
Description : NA
Used for/Prescribed for : NA
Formulation : 16.50%
Form : Liquid
Route of administration : intramuscular

6. Brands : Hyperrab S/d
Company : Grifols Therapeutics Inc
Description : Rabies immune globulin is used together with rabies vaccine to prevent infection caused by the rabies virus. Rabies immune globulin works by giving your body the antibodies it needs to protect it against the rabies virus. Used for/Prescribed for : Rabies immune globulin is used together with rabies vaccine to prevent infection caused by the rabies virus.
Formulation : 150 unit
Form : Solution
Route of administration : intramuscular

7. Brands : Imogam Rabies Inj 150unit/ml
Company : Pasteur mÉrieux Serums Et Vaccins, s.a.
Description : Imogam Rabies Pasteurised is a medicine containing the active ingredient(s) rabies virus immunoglobulin.
Used for/Prescribed for : Rabies immune globulin is used together with rabies vaccine to prevent infection caused by the rabies virus.
Formulation : 151 unit
Form : Solution
Route of administration : intramuscular

8. Brands : Imogam Rabies Pasteurized
Company : Sanofi Pasteur Limited
Description : IMOGAM® Rabies Pasteurized [Rabies Immune Globulin (RIG), Pasteurized (Human)] is a sterile solution of antirabies immune globulins (10-16% protein) for intramuscular administration.
Used for/Prescribed for : It is indicated for post-exposure prophylaxis in persons suspected of exposure to rabies, who have not previously received a complete immunization regimen with a cell culture produced rabies vaccine.
Formulation : Human proteins ( mg) containing IgG-class human rabies immune globulins with a minimum titre of 150 IU/mL. Supplied in 2 mL vial s (300 IU) and 10 mL vials (1,500 IU).
Form : Solution
Route of administration : intramuscular

9. Hypersensitivity;
IMOGAM® Rabies should not be administered as repeat doses once rabies vaccination has been in itiated. Repeating the dose may interfere with maximum active immunity expected to develop from the rabies vaccine.
Fever,
pain,
soreness,
tenderness, or stiffness at the injection site,
Skin rash
Live virus vaccines, such as measles vaccine, should not be given for four months following Human rabies virus immune globulin administration because antibodies in the immune globulin preparation may interfere with the immune response to the vaccine.

10. References : http://www.drugbank.ca/drugs/DB11603