1. 30-s Chair stand test and 30 meter walk test – related to acute visits due to respiratory problems in COPD patients Results from the TIE-study
Regina Bendrik 1,2, Andrei Malinovschi 3, Marieann Högman3,
Karin Lisspers1, Björn Ställberg1, Kristina Bröms1,2, TIE-study-group
¹Dept. of Public Health and Caring Sciences Medicine, Uppsala University, Uppsala, Sweden
²Centre for Research & Development, Uppsala University/Region Gävleborg, Sweden
³Dept. of Medical Sciences, Uppsala University, Uppsala, Sweden
TIE= tools identification exacerbations

2. TIE-study Multicenterstudy in primary- and secondary care
Counties in Mid-Sweden:
Gävleborg, Dalarna, Uppsala
TIE is a prospectiv cohort study. We are still including patients. The goal is to include 600 patients. At baseline there are multiple tests for example physical tests, answering a questionnaire and spirometry. Follow-ups at one and two years after baseline. I will present baselinedata today.

3. Aim
Investigate if 30-meter walk-test or second Chair stand test are related to acute visits due to respiratory problems and exacerbations

4. Method COPD-diagnosis - physician and spirometry verified
Lung function - GOLD-stage 1-4
Age 69 years (range years)
299 patients (58% women)
No history of stroke/TIA

5. Method Physical capacity Time to walk 30 meters at maximal velocity
Number of repetitions of 30-s Chair stand test 
Acute visits due to respiratory problems and exacerbations during last year were assessed by questionnaire
Exacerbation is defined as acute visit due to respiratory problems and treated with antibiotica or oral steroids.

6. Result A trend to longer time to walk 30m and fewer repetitions in Chair-stand test with more severe GOLD-stage
GOLD stage %
30m walk test (s)
Chair stand 30-s (times)
1 (n=22) 7
20.8
11.9
2 (n=162) 54
19.0
11.7
3 (n=86) 29
21.8
10.5
4 (n=29) 10
24.6
9.8
P<0.001

7. Results Acute visits last year were related to longer time to walk 30m and fewer repetitions of sit to stand
30m walk test
Acute visits (n=109)
No acute visits (n=187)
21.5
19.8
P=0.03
30-s Chair stand test
Acute visits (n=109)
No acute visits (n=187)
10.5
11.6
P =0.003

8. Results A history of COPD exacerbations last year were related to fewer repetitions of sit to stand
30m walk test
Exacerbations (n=87)
No exacerbations (n=204)
21.2
19.9
P=0.10
30s Chair stand test
Exacerbations (n=85)
No exacerbations (n=201)
10.4
11.5
P=0.008

9. Results 30-s Chair stand test
Fewer repetitions of sit-to stand related to
acute visits (p=0.008)
exacerbations (p=0.04)
(adjusted for lung function, gender, age and current smoking)

10. Conclusion
Data suggest a relation between 30-s Chair stand test and a history of acute visits due to respiratory problems and exacerbations in patients with COPD
Further studies should look at the prospective value of the test as well as its’ additive value to lung function measurements

11. Thank you! TIE-study group regina.bendrik@regiongavleborg.se
Marieann Högman Professor Dept. of Medical Sciences, Uppsala University, Uppsala, Sweden; Centre for Research & Development, Uppsala University/Region Gävleborg
Andrei Malinovschi MD, Associate Professor, Dept. of Medical Sciences, Uppsala University, Uppsala
Björn Ställberg MD, PhD, Dept. of Public Health and Caring Science, Family Medicine and Preventive Medicine, Uppsala University
Karin Lisspers MD, PhD, Dept. of Public Health and Caring Science, Family Medicine and Preventive Medicine, Uppsala University
Kristina Bröms MD, PhD, Centre for Research & Development, Uppsala University/Region Gävleborg, Sweden; Dept. of Public Health and Caring Sciences, Uppsala University
Christer Janson MD, Professor, Dept. of Medical Sciences, Uppsala University, Uppsala
Hans Hedenström MD, Associate Professor, Dept. of Medical Sciences, Uppsala University
Hirsh Koyi MD, PhD, Centre for Research & Development, Uppsala University/Region Gävleborg
Eva Brandén MD, PhD, Centre for Research & Development, Uppsala University/Region Gävleborg
Jonas Lundkvist Health Economist, PhD, Dept of Pharmacy, Uppsala University, Sweden
PhD students
Alexandra Thornadtsson PhD student, Centre for Research & Development, Uppsala University/Region Gävleborg, Dept. of Medical Sciences, Uppsala University, Uppsala
Margareta Gonzaléz Lindh SLP, PhD student, Centre for Research & Development, Uppsala University/Region Gävleborg, Dept. of Neuro Science, Uppsala University
Jens Ellingsen MD, PhD student, Dept. of Medical Sciences, Uppsala University
Johanna Sulku Clin. Pharmacist, PhD student, Centre for Research & Development, Uppsala University/Region Gävleborg, Dept. of Pharmaceutical Biosciences, Uppsala University
Regina Bendrik Physiotherapist, PhD student, Centre for Research & Development, Uppsala University/Region Gävleborg, Dept. of Public Health and Caring Sciences, Uppsala University