1. Nanomedicine Research at OU
Roger Harrison, Ph.D.
Professor
School of Biomedical Engineering
School of Chemical, Biological and Materials Engineering
OU Health Sciences Center Biomedical Engineering Symposium
March 24, 2017

2. What Is Nanomedicine?
Nanomedicine is the medical application of nanotechnology.
Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even future applications of molecular nanotechnogy such as biological machines.
Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials.
Distinct from the field of Molecular Medicine, a broad field where physical, chemical, biological, bioinformatics and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them.

3. Nanomedicine Researchers at OU
OU-Norman - include:
Michael Detamore – Biomedical Engineering
Nanoparticles in tissue engineering
Roger Harrison – Biomedical Engineering, and Chemical, Biological and Materials Engineering
Targeted single-walled carbon nanotubes for photothermal therapy of cancer and targeted gold nanoparticles for imaging tumors
Chaunbin Mao – Chemistry and Biochemistry
Phage nanomedicine for various applications
Vassilios Sikavitsas – Biomedical Engineering
Nano- and micro-scale features of tissue scaffolds for tissue engineering

4. Nanomedicine Researchers at OU
OU Health Sciences Center - include:
Priyabrata Mukherjee – Pathology and Stephenson Cancer Center
Nanoparticles for cancer therapy, including gold nanoparticles
Rajagopal Ramesh – Pathology and Stephenson Cancer Center
Nanoparticles for gene and drug delivery for cancer treatment and exosomes for cancer therapy

5. Detamore Research Group
Nanoparticles for tissue engineering:
Hydrogel precursor solutions
Tissue matrix – for example, cartilage particles

6. Harrison Research Group
Single-walled carbon nanotubes for cancer therapy:
Modes of heating:
Near-infrared light
Radiofrequency field
Bladder cancer
Breast cancer
Melanoma
Eye cancer
Brain cancer
Prostate cancer
Gold nanoparticles for imaging:

7. Sikavitsas Research Group
Nano- and micro-scale materials for tissue engineering:
Orthopedic tissue engineering, including for tendons and bones
Heparin functionalized
PLLA fiber
Polylactic acid scaffolds

8. Mao Research Group Phage nanomedicine applications: Gene/drug delivery
Vaccines
Tissue regeneration
Directing the fate of stem cells
Templating materials
Self assembly

9. Mukherjee Research Group
Gold nanoparticles for cancer therapy:
Inhibition of growth and metastasis
Modulation of trafficking and mechanism of antibody-induced receptor endocytosis
Effect of nanoparticle surface charge at the plasma membrane

10. Y Ramesh Research Group
Multifunctional nanoparticles for tumor-targeted delivery and imaging:
Lipids
Polymers
Gold
Applications for lung, breast, ovarian, and melanoma
Exosomes as drug delivery vehicles for cancer therapy (“nanosomes”) Y
Targeting Ligand
Gene
therapeutic
Chemodrug
Imaging agent
Nanosomes