1. Department of Anaesthesia and Intensive Care
34th SSAI Conference, Malmö 2017
Cooling in Sepsis Should fever be treated in ICU patients with infection or sepsis?
Morten H. Bestle, MD, PhD, EDIC, Ass. Professor
Nordsjællands Hospital, Hillerød,
University of Copenhagen, Denmark

2. Overall Conclusions 1
Fever in infected patients in the ICU is associated with a lower mortality and shorter hospital stays.
In infected ICU patients, antipyretic therapy seems to be safe, but does not reduce mortality or length of stay.
In septic shock, antipyretic therapy by (external cooling to normothermia) show improved hemodynamics and reduced early mortality .

3. Overall Conclusions 2 Mild induced hypothermia (MIH):
Has multiple effects in septic shock.
Animal studies of MIH for hours generally show improved organ function and survival.
Functional coagulation seem to be improved.
It remains unclear whether MIH can improve the prognosis in septic shock.
The CASS study will bring clarity to this.