1. TO IMPROVE THE AVAILIBILITY OF ACT
THE ARTEPAL PROJECT
TO IMPROVE THE AVAILIBILITY
OF ACT
Nairobi03/2006

2. ARTEPAL 1/ THE PROJECT PROJECT OF AEDES FOUNDATION
Agreed and financed by E.U. on 3 years
3 sections: technology transfer, pregnant women, distribution
Oteci (senior-experts) in charge of technology transfer under control of a technical and scientific committee.
OBJECTIVE: IMPROVE AVAILIBILTY OF ACTs
Nairobi03/2006

3. ARTEPAL 2/SITUATION
Evaluation of projects in all the supply chain (plantations, extraction, pharma) and in different regions
Evaluation of extraction processes
Establishing connections between different partners
Support in GMPs at different levels in connection with WHO/pre-qualification.
Nairobi03/2006

4. ARTEPAL 3/ FINDINGS
Numerous projects restarting basic studies available in the literature
Numerous plantation projects without available extraction unit.
Numerous projects without knowledge of the commercial possibilities and quality requirements
Numerous questions asked to WHO/RBM/MMSS and others
Nairobi03/2006

5. ARTEPAL 3/FINDINGS
Since the meeting in Arusha, risks of inadaptation of demand and supply are increasing.
Quantities
Quality
Recommandation of WHO for only ACTs may deeply change the demand
Nairobi03/2006

6. ARTEPAL 4/PROPOSAL S
WHO/RBM/MMSS with MSH/RPM Plus intend to produce a guide to API production covering :
Cultivation issues on artemisia annua:
Seeds: sourcing, quantities needed
Planting, growing conditions, climate…
Areas of cultivation and surfaces
Major issues, agricultural and financial
Average biomass and artemisini content
Nairobi03/2006

7. ARTEPAL 4/PROPOSALS Production of Artemisinin Extraction units:
Where
Capacity, quantity and time of production
Kind pf process
Possibilities to extract other products
Constraints: technical, financial
Issues involved with respect to the quality of finished ACTs:
GAP
GMP
DMF…
Nairobi03/2006

8. ARTEPAL 4/PROPOSALS Main deliverable:
« Market analysis »of the current situation in terms of capacity, quality issues,..
A guide for resources, contacts
Table or tool to estimate cultivation and extraction needs across the production chain.
Nairobi03/2006