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Taxol and the Pacific Yew Tree

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1 Taxol and the Pacific Yew Tree
Tayler Barnard and Sydney Allison Summer Bridge 2013, Appalachian State University

2 What is Taxol Extract from the Pacific Yew Tree
Used for cancer treatments Taxol named after the botanical name for Yew tree, Taxus brevifolia What is Taxol

3 The History of Taxol Found in the 1960’s by Jonathon Hartwell
Arthur Barclay isolated the active compound Natural Products Laboratory discovered what the identity of the active compound was The History of Taxol

4 The Structure of Taxol Discovered using X-ray crystallography
Cancer cells contain protein Bcl-2, which allows the cancer cells to continue multiplying Protein Bcl-2 stops apoptosis Taxol binds to protein Bcl-2 The Structure of Taxol

5 Clinical Trials 1983 – initial phase I studies abandoned
Taxol formulated in cremophor Neutropenia is combined with Taxol and limits Taxol’s toxicity Need to be paired with another chemical with exact dosing Most promising drug Clinical Trials

6 Taxol and Cancer Helps mostly ovarian and breast cancer
The meeting of the American Society of Clinical Oncology in San Diego in 1992 Taxol and Cancer

7 Putting the Pacific Yew Tree in Danger
1kg of Taxol requires 9000kg of bark from 2-3 thousand trees Need about 3 trees to help one patient Trees are limited and they are slow growing Cutting down large amounts of trees lead to their extinction Putting the Pacific Yew Tree in Danger

8 Saving the Pacific Yew Tree
Make Synthetic Taxol A group of French scientists developed a way to make 10-DAB, a “relative” to Taxol Use pine needles from English Yew to get 10-DAB Florida State University scientists used taxusin, to make synthetic Taxol Developed fully synthetic Taxol Saving the Pacific Yew Tree Taxol

9 1. "The Story of Taxol. " Pharmacognosy. N. p. Web. 28 Jul 2013
1. "The Story of Taxol." Pharmacognosy. N.p.. Web. 28 Jul < 2. "Serendipity: Cell Structure Study Uncovers Taxol's Secrets." National Science Foundation. National Science Foundation, 07 Jan Web. 28 Jul "Taxol." Lancet (06/13/1992): Web. 28 Jul Stephenson, Frank. "A Tale of Taxol." Florida State Office of Research. Florida State Office of Research, n.d. Web. 28 Jul Kolata, Gina. "Tree Yields a Cancer Treatment, But Ecological Cost May Be High." The New York Times. The New York Times, 13 May Web. 28 Jul "About Pacilitaxel." Vital Aid Net. N.p.. Web. 28 Jul < References

10 Dr. Rahman Tashakkori Dr. Alexander D. Schwab Professor Nathan Weigl Dr. Katrina Palmer Professor David Sittar Dr. Cindy Norris Dr. Jennifer Burris Zachary Andrews Kristen Vroom Noah Hughes Michael Kelly Appalachian State University Academy of Science Summer Bridge Program National Science Foundation Acknowledgements


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