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Triple-Negative and BRCA-Mutated Metastatic Breast Cancer

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Presentation on theme: "Triple-Negative and BRCA-Mutated Metastatic Breast Cancer"— Presentation transcript:

1 Triple-Negative and BRCA-Mutated Metastatic Breast Cancer

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3 TNBC Overview

4 TNBC Subtypes

5 Case Overview

6 Recommended Regimens for the First-Line Treatment of MBC

7 TNT Study: Carboplatin vs Docetaxel in Advanced TNBC or BRCA1/2-Positive MBC

8 tnAcity: Phase 2 Trial of Nab-Paclitaxel and Carboplatin in Front-Line Metastatic TNBC

9 Androgen Signaling and TNBC

10 Targeting the AR Pathway in TNBC Bicalutamide

11 Phase 2 Single-Arm Study of Bicalutamide in AR-Positive, ER-Negative MBC

12 Targeting the AR Pathway in TNBC Enzalutamide

13 Phase 2 Study of Enzalutamide in Advanced AR-Positive TNBC

14 ENDEAR: Phase 3 Trial of Enzalutamide-Positive Paclitaxel in Advanced Diagnostic-Positive TNBC

15 UCBG 12-1: Phase 2 Trial of Abiraterone Acetate-Prednisone in Advanced AR-Positive TNBC

16 Phase 1b/2 Data for Pembrolizumab in Advanced TNBC

17 Ongoing Studies of Immune Checkpoint Inhibitors in Advanced TNBC

18 PARP Inhibitors in TNBC

19 Randomized Phase 2 Trial of Veliparib and Cyclophosphamide in Advanced TNBC

20 Phase 1 Trial of Olaparib and Paclitaxel in TNBC

21 PARP Inhibitors in BRCA-Mutated MBC

22 Phase 2 Study of Lurbinectedin in BRCA-Mutated MBC

23 Antibody-Drug Conjugates in Development for TNBC

24 Concluding Remarks

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