1. Highlights from INFN-MED
the INFN strategic project for Medicine
Areas of interest:
Imaging
Treatment Planning and Software projects
Accelerator devices for Hadron Therapy
BNCT
Devices for Medical Diagnostics

2. Imaging: MAGIC-5 Project
Fall out from the experience in the analysis of particle phyiscs experiments
A highly competitive lung CAD (Computer Assisted Detection) has been developed, capable of speeding up diagnosis response in case of large screenings.
Based on the development of different and complementary pattern recognition algorithms.
Several recognitions at international level.
Looking for an industrial partner to turn the prototype into a market product

3. (for instance Alzheimer Disease)
Neuroimaging
For the understanding and early diagnosis of pathophysiological mechanisms of neurodegenerative diseases
(for instance Alzheimer Disease)
Promising results
work with the European Alzheimer’s Disease Consortium (EADC)
Plans:
Full MRI/PET combined analysis
Development of more efficient computational tools
WWW access to the clinical world
Furthermore, side product from Magic-5:
development of an innovative web service to manage Clinical Trials (diXit). Particularly useful for the experimentation in pharmacology

4. Treatment Planning System for therapy with C ions
Fall out from the experience in software management, simulation tools, radiobiology and nuclear phsycs
Collaboration Agreement with IBA . Development of .innovative system to be embedded in the “Oncology Information System” (OIS) in a configuration known under the name of MOSAIQ-RTP (Commercialized by Eleckta-CMS, controlled by IBA)

5. Status of development To Be Released October 2010 Plan To Be Released
April 2010
Released April 2010
Released August 2010
To Be Released January 2011

6. Complete the design of a new Accelerator Source: MISHA
Multicharged Ion Source for HAdrontherapy
At CNAO center for hadrontherapy two ECR sources of the SUPERNANOGAN type (built by the Pantechnik company according to specifications set by INFN) are in operation.
A further increase of accelerator reliability involves the improvement of the beam brightness, which can be achieved with the design and construction of a new ECR ion source, able to provide more than 600 eµA of C4+ with an emittance figure of 0.75π mm. mrad.
The MISHA source will be a multipurpose device, providing enough versatility for future needs of the hadron therapy. The MISHA source has been designed on the basis of the expertise existing in INFN Labs (LNS and LNL, G. Ciavola et al.)
Of interest for all accelerators for hadrontherapy

7. General layout of the MISHA source and of its Low Energy
Maximum radial field
1.3 T
Maximum axial field
2.5 T / 1.5 T
Frequency
18 GHz GHz
Maximum RF power
500 W W
Maximum extraction field
50 kV
Chamber diameter
Ø 92 mm
LHe
free
External Funding is being
searched for
(~1.5 M€ needed)
General layout of the MISHA source and of its Low Energy
Beam Transfer line

8. MID (under completion)
Fall out from the experience in the development of high precision magnetic
apparata in particle physics.
First device capable of measuring the amount of Fe in human organs in a non invasive way (i.e. avoiding biopsy). From the experience of INFN Genova, co-financed and in under operation in Galliera Hospital (Genova).

10. ECORAD
Fall out from the experience in the development of new particle detectors
Now exploring Patent/Technology Transfer possibilities
Resp.: R.Pani, INFN and Roma 1 Univ.

11. A first presentation of the project will take place in LNL/Padova
New possibilities
Design study for a facility to produce Radionuclides for Medicine using the new cyclotron at LNL
LARAMED
A first presentation of the project will take place in LNL/Padova
at the end of November:

12. Relationships with CNAO and Healt Ministry
Monitoring cooperation with CNAO foundation for hadron therapy in view of:
MC Simulation
Pre-clinic activity
Treatment Plannig evolution
Definition of collaboration agreement with Health Ministry for scientific exchange, relationship with industry in medical sector, cofinancing of activities of common interest