1. Clinical Experience of an Iontophoresis Based Glucose Measuring System
Sang Youl Rhee*,., Suk Chon*,.,Gwanpyo Koh*,., Jeong Ryung Paeng.,Seungjoon Oh*,., Jeong-taek Woo*,.,
Sung Woon Kim*,., Jin-Woo Kim*,.,Young Seol Kim*,.
Departments of Endocrinology and Metabolism*,
Research Institute of Endocrinology., College of
Medicine, Kyung Hee University, Seoul, Korea
J Korean Med Sci 2007; 22: 70-3
ISSN
Prof. Sang Youl Rhee
R1 Jun Wook Lim

2. INTRODUCTION - The need of appearance of RIGMD
FINGER PRICKING METHOD
- Apprehension, Pain, Low compliance
LIMITED INFORMATION OF GLUCOSE LEVEL CHANGES
- Frequency of glucose level checking is 4 times a day
CGMS (CONTINUOUS GLUCOSE MONITORING SYSTEM)
- Not easily operated by a patient TM

3. INTRODUCTION – The principle of Gluco-watch and RIGMDTM
GLUCO-WATCH
- It is the first commercially useful device
- Non invasive continuous method of measuring glucose
concentration in interstitial fluid by reverse iontophoresis
RIGMD (Reverse Iontophoresis based Glucose Monitoring Device)
- Measures interstitial fluid glucose concentrations via an electrochemical enzymatic sensor every 5min. TM

4. AIM OF THIS STUDY
To investigate the accuracy and clinical acceptability of this new device by comparing the data obtained from it and plasma glucose levels obtained by venous sampling.

5. REVERSE IONTOPHORESIS
MATERIALS AND METHODS
OPERATIONG PRINCIPLE OF RIGMD
- Experiments conducted in vivo in 1995
Sensor
Glucose
oxidase
Glucose+O Glucuronic acid+ H2O2
2e- + O2+ 2H
Glucose concentration
Skin
Electrode
Electrode
Microcurrent
REVERSE IONTOPHORESIS
Glucose

6. MATERIALS AND METHODS STUDY SUBJECTS DATA ANALYSIS
- 28 type 1 and type 2 diabetes mellitus patients admitted to the Kyung Hee University Hospital
- November January 2004.
- Nine of the 28 candidates were excluded
The exclusion criteria
1) continuous hypo- or hyperglycemia
(<40 mg/dL or >450 mg/dL);
2) electronic auxiliaries fitted such as
cardiac pace maker;
3) an abruption or injury to forearm skin;
4) acetaminophen administration within 72 hr
of the initiation of the data collection; .
5) mentally illness;
6) peripheral vascular disease; or
7) anemia.
Acetaminophen is known to potentially interfere with conventional glucose monitoring devices
STUDY PROTOCOL
1) RIGMD vs venous blood sampling
2) Checked hourly in each patient
3) From 10 a.m. to 4 p.m.
DATA ANALYSIS
1) SPSS Version 11.0
2) The Clarke error grid analysis
3) linear regression analysis

7. RESULTS - 1

8. RESULTS - 2

9. RESULTS - 3

10. RESULTS - 4

11. RESULTS - 5

12. DISCUSSION CORRELATION COEFFICIENT
Gluco Watch biographer studies > RIGMD (r=0.784)
Fewer subjects lower reliability
Gluco Watch using the finger prick method
Effection location, skin thickeness, temperature,
perspiration
Not sufficiently reliable, not accurate enough to replace conventional methods of monitoring glucose