1. Per2
Bmal1
Per3
Cry2
Cry1
Clock
Ror
CSNK1
Per1
Rev-erb
0.05
0.1
0.15
0.2
0.25
0.3
0.35 A B D C
Supplemental Figure 3. Cross-correlation analyses of clock gene expression in human peripheral blood leukocytes challenged with endotoxin or saline at 09:00 h or 21:00 h. The gene expression data for each subject was cross-correlated across all studied genes within a subject. The cross-correlation data were normalized to one, where one represents a perfect correlation between gene responses. The correlation matrices for (A) placebo day and night subjects (09:00 h plus 21:00 h saline infusion time; n=3), (B) endotoxin day subjects (09:00 h infusion; n=4), (C) endotoxin night subjects (21:00 h infusion; n=3), (D) endotoxin day and night subjects (09:00 h plus 21:00 h endotoxin infusion time; n=7), were clustered into a tree form.