Presentation is loading. Please wait.

Presentation is loading. Please wait.

Date of download: 10/10/2017 Copyright © ASME. All rights reserved.

Similar presentations


Presentation on theme: "Date of download: 10/10/2017 Copyright © ASME. All rights reserved."— Presentation transcript:

1 Date of download: 10/10/2017 Copyright © ASME. All rights reserved. From: Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations J Biomech Eng. 2008;130(2): doi: / Figure Legend: Solute concentration along the wall in the infusion region (Region I in Fig. ). The analytical solution was calculated using Eq. , and parameters used in the calculations are listed in Table .

2 Date of download: 10/10/2017 Copyright © ASME. All rights reserved. From: Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations J Biomech Eng. 2008;130(2): doi: / Figure Legend: Plots of (B∕dx+1)2∕3 versus 1∕Cw in Region II (see Eq. ), obtained from results of FEM simulations for different values of D. The diffusion coefficients employed in the simulations are as follows : thrombin (Th), D=10−11m2∕s (this value represents only the order of magnitude of D for thrombin); heparin (Hep), D=10−10m2∕s; NO, D=10−9m2∕s. Other parameters used are listed in Table .

3 Date of download: 10/10/2017 Copyright © ASME. All rights reserved. From: Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations J Biomech Eng. 2008;130(2): doi: / Figure Legend: Wall concentration of a solute infused through three wall regions of equal length (d=1mm) separated by regions (of length 1mm) with no transfer through the wall. Concentrations obtained by adding contributions from single infusion regions, calculated using Eqs. , were compared to concentrations obtained with FEM. Other parameters employed in the calculations are shown in Table .

4 Date of download: 10/10/2017 Copyright © ASME. All rights reserved. From: Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations J Biomech Eng. 2008;130(2): doi: / Figure Legend: Dynamic variation of wall concentration during oscillatory flow (obtained with FEM) at two different wall locations. Flow rate oscillated sinusoidally between 100ml∕min and 300ml∕min. Diamonds, end of infusion region (x=0mm); squares, x=50mm. Note that the concentration scales at x=0 and x=50mm are different, and that the amplitudes of oscillation are much smaller than those of a quasisteady oscillatory flow (see also Table ). Other parameters employed in the calculations are shown in Table .


Download ppt "Date of download: 10/10/2017 Copyright © ASME. All rights reserved."

Similar presentations


Ads by Google