1. Konzern Group Limited

2. Company Overview
CMC (China Medicine Corporation) registered in Nevada, USA, is a comprehensive enterprise with a research and development centre, manufacturing facilities and well established sales network, engages in the production and distribution of prescription and over the counter ("OTC") drugs, traditional Chinese medicine products, herbs and dietary-supplements, medical devices, and medical formulations in China.
Konzern Group Limited (Guangzhou, China) is a wholly-owned subsidiary of CMC.
Guangzhou Co-win Bioengineering Co., Ltd ("Co-Win") is a high-tech enterprise which was jointly founded in 2006 by Jinan University and Konzern Group Ltd. 25 million Chinese Yuan was initially invested. Co-Win focuses on the industrialization of high-tech projects and is currently advancing the R & D and production of Aflatoxin B1-detoxifizyme and its related products, a national "863" high-tech project.

3. Contaminated cottonseed(a), corn(b), and rice(c)
Biotech Innovation
Aflatoxin-detoxifizyme (ADTZ)
What is AFT?
A kind of mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus Speare.
Including Aflatoxin B1,B2,G1,G2,M1 and M2 etc, among which AFB1 is the most toxic.
Aspergillus flavus prefer warm and moist conditions to grow and produce toxins; most feed and food could be contaminated, such as peanut, corn, rice and milk.
Aspergillus flavus
Structure of AFB1 a b c
Contaminated cottonseed(a), corn(b), and rice(c)

4. AFT Biotech Innovation death AFT is very toxic
AFT has been classified as carcinogen of Group A by IARC, could cause human gastric carcinoma, liver cancer and lung cancer etc.
Toxicity of AFT is 10 times of hydrocyanic acid and 68 times of arsenic.
0.294 mg/kg AFB1 could cause susceptive animals die of acute toxicity.
Ways to harm human beings
AFT
food contamination
feed contamination
human
Birds and beasts
food chain
Serious poisoning
Light poisoning
Toxin accumulation
death
lose weight, get sick
tumor

5. Biotech Innovation
Aflatoxin-detoxifizyme (ADTZ)

6. Biotech Innovation
A New Fungi-found Enzyme: Aflatoxin B1-detoxifizyme (ADTZ)
Protein extracted from a kind of edible fungi.
Under mild conditions, ADTZ could interact with AFB1 to break the toxic structure bifuran and function as antidote against AFT.
First discovered and isolated in international wide, was proved to be a new enzyme.
An innovative, China-source discovery.
Independent Intellectual Property Rights.（ Patents were granted to aflatoxin B1-detoxifizyme in 21 counties and regions, including the United States , European Union and Japan ）
Authorized by Ministry of Agriculture of PRC, No. : (2010) 02

7. COWINZYM Feed additive——Aflatoxin B1-detoxifizyme
Products
COWINZYM Feed additive——Aflatoxin B1-detoxifizyme
label
【Product Ingredients Analysis Certified Value】Activity of Aflatoxin B1-detoxifizyme≥6000 U/g; Crude Ash≤10%.
【Ingredients】Aflatoxin B1-detoxifizyme with furfur or other organic materials of same kind as carriers.
【Functions】
Reduce the residue of Aflatoxin B1 in the animal body （internal organs, blood and muscle）;
Protect livers and increase immune performance;
Reduce the subcutaneous hemorrhage caused by toxin and improve the quality of the carcass.
【Applicability】Feed for chicken and piglings.
【Direction for Use】6×106 ～ 3×107U /ton, mixed uniformly with ration.

8. of the other ingredients of the compound feed
Products
Cowinzym product inactive ingredient is organic,
thus environmental friendly and safe
Enzymatic detoxication without releasing any toxin and inducing any secondary pollution
Complete absorption，the inactive ingredient is organic, thus can be digested and absorbed by animals.
No adsorption
of the other ingredients of the compound feed

9. Cowinzym- deintoxication mechanism targeting at the mycotoxin synergism
Viruses
Bacteria
Trichothecenes
Voitoxin
T-2 Toxin
Aflatoxin
Ochracin
Patulin
Zearalenone
Fumitremorgin
protect liver
Improve
immunity
COWINZYM
By breaking down the aflatoxin and reducing the liver damages Cowinzym ensures the liver detoxifies toxicants and other toxin, thus the antitoxic and disease resistant effects are achieved.

10. Serum glutamic oxalacetic
Physiological and biochemical effects on broilers
Liver glutathione
peroxidase
Liver superoxide
dismutase（SOD）
Liver succinate
dehydrogenase（SDH）
Serum glutamic oxalacetic
transaminase（GOT）
Control group
Challenge group
Emzymatic challenge group
Improve the antioxidant capacity of the liver
and reduce the liver damage
caused by the toxin

11. Increase average daily weight
Improve the production performance of the AA broilers
+4.8%
Increase average daily weight
gainand feed intake
Average daily weight gain
Control group
Challenge group
Emzymatic challenge group
+3.25%
Average daily feed intake

12. Protect the physiologic functions of the liver
Physiological and biochemical effects on Piglets
Protect the physiologic functions of the liver
Liver catalase(CAT)
Liver glutathione transferase(GR)
Serum glutamic pyruvic
transaminase(GPT)
Serum glutamic oxalacetic
transaminase(GOT)
Control group
Challenge group
Emzymatic challenge group

13. Increase the feed intake Increase the body weight gain
Improve the production performance of the piglets
Body weight gain (kilo/pig)
Control
group
Challenge
Emzymatic
challenge
Feed intake (kilo/pig)
Control
group
Challenge
group
Emzymatic
challenge
group
Increase the
feed intake
Increase the body
weight gain

14. Experiment conclusion
Cowinzym can protect the animal liver and improve the animal immunocompetence .
Cowinzym can improve the production performance.
Using Cowinzym can bring significant economic benefits .

15. Aflatoxin-detoxifizyme (ADTZ)
Quality Standards
Items
Specifications
Formulation
Farinose solid, yellowish to fawn
Granularity(2.00 mm standard sieve)
≧99%
Enzymatic activity of Aflatoxin B1- detoxifizyme
≧6000 U/g
Crude ash
≦10%
﹡The permissible dose is based on the feed with the dry matter content of 88%.

16. International Trade Department
International Cooperation
Eleanor Luo
International Trade Department
Tel:
Fax:
Looking for Agents, Distributors and Cooperators all over the world