1. American Evaluation Association
The International Cancer Research Partnership: A Global Collaboration Enabling Analyses of Sponsor-Funded Cancer Research
Panel Session 2549
American Evaluation Association
EVALUATION 2015
November 11, 2015

2. Kari Wojtanik and Lynne Davies
Session Presenters
Elizabeth Hsu
Session Chair
Miranda Kleijn
Translational Research: Monitoring Trends in the International Cancer Portfolio
Senaida Poole
Prevention Research: Utilizing a Global Database to Identify and Act on Trends in Research Funding
Kari Wojtanik and Lynne Davies
Global Assessment of Funding Trends Across a Diverse Spectrum of Issues in Breast Cancer Research
Samantha Finstad
Assessment of the International Cancer Research Partnership Lung Cancer Portfolio

3. ICRP: adding value to cancer research
ICRP’s mission is to add value to cancer research efforts internationally by fostering collaboration and strategic co-ordination between cancer research organizations.
Mission
ICRP Chair : Dr. Miranda Kleijn
Vice-Chair: Dr. Katie McKenzie

4. History & milestones
2000
Cancer “CSO” classification tool developed by NCI & CDMRP
8 organizations invited to join
2003
First generation website launched
2010
Agreement to share full data between Partners
2011
New website launched to Partners, giving access to improved analytical tools
2012
Public launch of new ICRP site
First international analysis of cancer research ( ) published
2015
Data from 109 organizations included in the ICRP database
Planned launch of 2nd International analysis of cancer research (2005+)
Brief history & milestones

5. Who is involved? Coalition against Childhood Cancer & Cancer Institute NSW new in 2015

6. ICRP Coding and Database
Participating organizations/agencies share high quality, coded data
The ICRP database contains data on more than 76,000 grants from 109 organizations (> $6bn p.a.) and is expanding every month. We use this unique resource to ask:
What are the gaps in cancer research?
What are the trends in cancer research funding?
What types of projects have been funded (e.g. clinical, research, training)?
What research areas are being funded (CSO)?
What types of cancer are being funded?
What is the funding profile across different countries and organizations?
How can we maximize our research efforts?
How can we foster strategic collaborations between funding organizations?
What we do – data
No. of orgs correct as of 1 April 2014

7. Common Scientific Outline (CSO) (ver 2)
1. Biology
1.1 Normal functioning
1.2 Chromosome alterations
1.3 Oncogenes and tumor suppressor genes
1.4 Progression and metastasis
1.5 Resources and infrastructure
2. Etiology
2.1 Exogenous factors
2.2 Endogenous factors
2.3 Interactions
2.4 Resources and infrastructure
3. Prevention
3.1 Behavior interventions
3.2 Dietary interventions
3.3 Chemoprevention
3.4 Vaccines
3.5 Complementary and alternative approaches
3.6 Resources and infrastructure
4. Early detection, diagnosis and prognosis
4.1 Development and discovery
4.2 Evaluation
4.3 Testing in clinical setting
4.4 Resources and infrastructure
5. Treatment
5.1 Localized - Development
5.2 Localized - Clinical
5.3 Systemic - Development
5.4 Systemic - Clinical
5.5 Localized + Systemic
5.6 Complementary and alternative approaches
5.7 Resources and infrastructure
6. Control, survivorship, outcome
6.1 Care and survivorship
6.2 Surveillance
6.3 Behavior
6.4 Health services
6.5 Education
6.6 End-of-life care
6.7 Ethics
6.9 Resources and infrastructure
CSO v2 released in April Coding modified to adapt to evolution in science/research, and learned from strengths/weaknesses of version 1. Further details on this will be given in the prevention presentation.

8. Cancer Site Codes 47 cancer site codes
9 ‘roll up’ codes (e.g., urinary cancers, blood cancers)
Coded with a “percent relevance” to the site; may sum to more than 100%

9. Enables structured searches of 1000s of awards
Comprehensive search functionality
Users can search by year, organization, city, country, CSO, cancer type, keyword, project type, PI Name….

10. ICRP: data at the touch of a button
Lung cancer research by CSO code, internationally
Oesophageal cancer research in the UK

11. Understanding the cancer research landscape
ICRP publishes regular data reports
benchmark analysis of cancer research funding
trend analysis of international cancer research (publication due in 2015)
ICRP data contributes to topic-specific reports led by ICRP or partner organizations
Recent ICRP publications:
Obesity & cancer (2014)
Environmental influences on breast cancer (2014)
Metastatic breast cancer (2014)
How data helps – ICRP report ( data), included in other reports too

12. Enabling Cross-Funder Multinational Analyses
All grants submitted to the ICRP database are classified by
CSO “Type of research”
Cancer site “Type of cancer”
ICRP partners and staff are also developing new tools and methodologies to mine this dataset in more detail
Cross-cutting analysis using keywords, boolean searches
Extracting award data and adding meta-data through a combination of semi-automated and manual coding
Investigating new tools in partnership with others to add value to the data
Case studies presented today:
Translational research: monitoring trends in the international cancer portfolio
Prevention research: Utilizing a global database to identify and act on trends in research funding
Global assessment of funding trends across a diverse spectrum of issues in breast cancer research
Assessment of the International Cancer Research Partnership lung cancer portfolio