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Volume 17, Issue 5, Pages 600-611 (May 2016)
Bevacizumab plus neoadjuvant chemotherapy in patients with HER2-negative inflammatory breast cancer (BEVERLY-1): a multicentre, single-arm, phase 2 study Prof François Bertucci, MD, Mahmoud Fekih, MD, Aurélie Autret, MSc, Prof Thierry Petit, MD, Florence Dalenc, MD, Christelle Levy, MD, Gilles Romieu, MD, Prof Jacques Bonneterre, MD, Prof Jean-Marc Ferrero, MD, Prof Pierre Kerbrat, MD, Patrick Soulie, MD, Marie-Ange Mouret-Reynier, MD, Thomas Bachelot, MD, Florence Lerebours, MD, Jean-Christophe Eymard, MD, Mathilde Deblock, MD, Alain Lortholary, MD, Anne-Claire Hardy-Bessard, MD, Philippe Barthelemy, MD, Prof Hervé Bonnefoi, MD, Prof Emmanuelle Charafe- Jauffret, MD, François-Clément Bidard, MD, Prof Patrice Viens, MD, Jérôme Lemonnier, PhD, Prof Jean-Yves Pierga, MD The Lancet Oncology Volume 17, Issue 5, Pages (May 2016) DOI: /S (16) Copyright © 2016 Elsevier Ltd Terms and Conditions
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Figure 1 Study design Dotted line on the box under radiotherapy, which represents bevacizumab, shows that bevacizumab could be restarted during (concomitant) or after (sequential) radiotherapy once wound healing was complete. The Lancet Oncology , DOI: ( /S (16) ) Copyright © 2016 Elsevier Ltd Terms and Conditions
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Figure 2 Trial profile *Screening failures were not recorded. †These five patients were among the 18 who permanently discontinued neoadjuvant bevacizumab. The Lancet Oncology , DOI: ( /S (16) ) Copyright © 2016 Elsevier Ltd Terms and Conditions
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Figure 3 Disease-free survival and overall survival
Kaplan-Meier curves for disease-free survival (A) and overall survival (B). Number at risk is shown as 0 at 60 months because data are not yet available for this timepoint. The Lancet Oncology , DOI: ( /S (16) ) Copyright © 2016 Elsevier Ltd Terms and Conditions
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