1. Work Package 4 Extending Analysis – MeV-SIMS
SPRITE Final Meeting – 27/06/2016, Manchester
Work Package 4
Extending Analysis – MeV-SIMS
MeV ion beams to produce a
Secondary Ion Mass Spectrometry (SIMS) signal

2. SPRITE Work Package 4 Extending Analysis – MeV-SIMS Fellows
This Work Package, aims to exploit a joint research activity begun in SPIRIT which involves the use of MeV ion beams to produce a Secondary Ion Mass Spectroscopy (SIMS) signal for molecular concentration mapping on surfaces. This technique has begun to show considerable promise and to be better exploited needs to train new researchers in this analysis technique.

Fellows
Lidija Matjačić
ESR, Surrey
Valentin Stoytschew
ESR, RBI
Julien Demarche
ER, Surrey/IAEA

3. The first real molecular analysis using ion beams!
MeV-SIMS
The first real molecular analysis using ion beams!
Low current technique (≈ fA)
Detected masses: ~ 1000 Da
High efficiency: ~ 0.1 secondary ion yield
103 higher yield for heavy molecules than keV SIMS
Molecular mapping

4. Vacuum and ambient pressure facilities, SUR (ESR9 – ER4)
Extending Analysis
Research Activities in Work Package 4
Vacuum and ambient pressure facilities, SUR (ESR9 – ER4)
Commissioning the MeV-SIMS Facility and beam pulser at RBI and ambient pressure MeV-SIMS Facility at Surrey
Measurements of fundamental parameters (yields, damaging cross-sections) -Investigation of sputtering mechanisms for MeV ions
3 Application of MeV-SIMS (vacuum and ambient pressure)
Develop protocols for sample preparation and inter-comparisons
Vacuum facility, RBI
(ESR10)

5. Milestones
ESR 9
M4.1 Identification of key parameters for optimum configuration of MeV SIMS analysis
M4.2 Demonstration of optimum MeV SIMS configuration for ambient pressure analysis
ESR10
M4.3 Time stamping software for MeV SIMS microbeam data acquisition, developed and tested
M4.4 Molecular imaging of paint layers cross sections using RBI MeV SIMS facility performed
ER 4
M4.5 Development of standard samples, organization of Round Robin measurements, for inter-comparison of the data, critical evaluation of the results

6. M4.4 Molecular imaging of paint layers cross sections using RBI MeV SIMS facility performed
Beam: 8 MeV Si4+
Sample: PB15:1 on PB15:3/glass
Scan Size=1.2 mm x 1.1 mm (128x128 pixels)
Iva Bogdanović Radović, Dubravka Jembrih-Simbürger, Zdravko Siketić, Nikola Marković, Milko Jakšić,Marta Anghelone and Valentin Stoytchew, Identification and imaging of modern paint materials using MeV-SIMS to be presented at ECAART 2016

7. IAEA Coordinated Research Project on MeV-SIMS
Launched in June 2014
Involving 12 worldwide partners, half of them from outside Europe (Australia, Brazil, Japan, South-Africa, Thailand)
Database building of measured cross sections for heavy ion PIXE appropriate for MeV-SIMS energy range
Development of spectrum library and protocols for routine MeV-SIMS multispectral data analysis
Development of best practice and protocols for sample handling to prevent cross-contaminations
Development of theoretical models validated by experimental data for a refined theoretical understanding of MeV heavy ion –soft matter interactions

8. Communications (Talks, Posters)
ESR9 Lidija Matjačić
UK Surface Analysis Forum Winter Meeting 2014 in Nottingham UK, poster Ambient Pressure MeV SIMS
CAARI 2014 poster Chemical characterisation of explosives residues by Ambient Pressure MeV-SIMS
NMAET VI Meeting 2014 in National Physical Laboratory poster on Measurements of MeV-SIMS yields and damage cross sections for a range of ions and energies
IBA 2015 poster Characterisation of Explosive Residues using MeV-SIMS and was a co-author on 4 other posters presented at the conference
SIMS XX Seattle, US, 2015, poster titled Characterisation of Explosives with Ambient Pressure MeV- SIMS and was a co-author on 2 other posters presented at the conference
2nd RCM on Development of molecular concentration mapping techniques using MeV focussed ion beams in Kyoto, Japan, 2015, presented results on development of Ambient Pressure MeV SIMS technique
Holding a seminar on Ambient Pressure MeV SIMS in Academy for Fine Arts in Vienna, as a part of ChemArt program - held on 14th of January  
Participating in Consultancy Meeting (F1-CS-5345) on the Design of the Technical Meeting on Enhancement of Multi-disciplinary Nuclear Analytical Applications for High-precision Trace Element and Molecule Fingerprinting and giving a talk on Ambient Pressure MeV SIMS
ECAART 2016, ICNMTA 2016, CAARI 2016
6th SPRITE Management Meeting 27th – 28th June 2016
Manchester Cancer Research Centre (MCRC), Wilmslow Road, Manchester

9. ESR10 Valentin Stoytschew
Talk at the 5th Science Festival of PhD students from Division of Experimental Physics.
ICNMTA 2014 Padova; poster Current measurement for low current microprobe techniques including MeV SIMS.
IBA 2015 Opatija, Croatia; poster Investigation of damage cross section and yield dependence on experimental parameters for MeV SIMS
MMC 2015, Manchester Central, UK, poster Megaelectronvolt Secondary Ion Mass Spectroscopy as a high resolution molecular imaging technique
SIMS XX Seattle, USA; poster Investigation of Damage Cross Sections and Yield Dependence on Experimental Parameters for MeV SIMS using in Situ Beam Current Monitoring
ECAART 2016, ICNMTA 2016
6th SPRITE Management Meeting 27th – 28th June 2016
Manchester Cancer Research Centre (MCRC), Wilmslow Road, Manchester

10. ER4 Dr Julien Demarche
CAARI 2014 in San Antonio, Texas presented a talk Pharmaceutical and biomedical application possibilities of ambient pressure MeV-SIMS and presented and co-authored a poster Ambient Pressure MeV-SIMS analysis of contaminated aerosols PTFE filters.
IAEA RCM (Research Coordination Meeting) held in June 2014 in University of Surrey, Guildford
IBA 2015 (22nd Conference on Ion Beam Analysis), held June 14-19, 2015 in Opatija, Croatia;
Presented three posters and co-authored three posters
took part and talked in the IAEA Panel on Ion Beam Techniques Roadmap
invited talk on Log-periodicity and the epistemic dynamics of Ion Beam Analysis research
SIMS XX (20th International Conference on Secondary Ion Mass Spectrometry) held September in Seattle, USA; co-authored two posters, Characterisation of Explosive Residues, and First Round Robin Exercise on Sample Handling and measurement protocol for MeV-SIMS.
IAEA 2nd Research Coordination Meeting of Coordinated Research Project F11019 – Development of molecular mapping techniques using MeV focussed ion beams; talked on Surrey Ion Beam Centre’s activity report.
6th SPRITE Management Meeting 27th – 28th June 2016
Manchester Cancer Research Centre (MCRC), Wilmslow Road, Manchester

11. Outreach Activities ESR9 Lidija Matjačić ESR10 Valentin Stoytchev
On 22nd of November 2014 University of Surrey, in collaboration with National Physics Laboratory organised event named International Day of Medical Physics. Dr Anne-Catherine Wéra and Marios Sotiropoulos from WP1 together with two representatives of WP4, Dr Julien Demarche and Lidija Matjačić prepared two posters and a short film which were presented during the poster session. First poster was describing Marie Curie Initial Training Network as one of the types of Marie Curie Actions (MCA). Other types of MCA such as Individual Fellowship (IF) or Research and Innovation Staff Exchange (RISE) were also described in to details. Second poster was explaining meaning and structure of SPRITE project.
ESR10 Valentin Stoytchev
SPRITE Project was presented by Valentin Stoytschew during 5th Science Festival of PhD students from Division of Experimental Physics that was held at RBI on April 24-25, 2014.
SPRITE Project was presented during the RBI’s Open Day, held on 14 June 2014
ER4 Dr Julien Demarche
Introduced SPRITE Project and detailed research activities in WP4 to IAEA Interns (undergraduate and postgraduate students in internship, with background in economics, law, political science) during an Interns Forum session at the IAEA Headquarter on 15 December 2014
Guided young students groups (16-18 years) through the Surrey Ion Beam Centre, and presented research activities of the SPRITE project in the IBC.
6th SPRITE Management Meeting 27th – 28th June 2016
Manchester Cancer Research Centre (MCRC), Wilmslow Road, Manchester

12. Secondments ESR9 Lidija Matjačić
RBI in Zagreb, from 17-24th of October 2014
JSI in Ljubljana, from 14th to 20th of February 2015
IAEA Headquarters, from 4th-29th of January 2016   
ESR10 Valentin Stoytschew
IAEA Laboratories Seibersdorf 10/ /2014;
IBC Surrey 2/2015;
ETH Zuerich March/April 2015;
ER4 Dr Julien Demarche
IAEA Headquarters: March 27 to May 3, 2014; November 9 to December 22, 2014; May 21 to June 6, 2015
RBI October 16 to 24, 2014
6th SPRITE Management Meeting 27th – 28th June 2016
Manchester Cancer Research Centre (MCRC), Wilmslow Road, Manchester

13. Publications
 1. J. Warmenhoven, J. Demarche, V. Palitsin, K.J. Kirkby, R.P. Webb; Modeling Transport of Secondary Ion Fragments into a Mass Spectrometer, Physics Procedia 66(2015)3521.
2. V. Stoytschew, I. Bogdanović Radović, J. Demarche, M. Jakšić, L. Matjačić, Z. Siketić, R. Webb; MeV-SIMS yield measurements using a Si-PIN diode as a primary ion current counter, Nucl. Instr. and Meth. B 371 (2016) 194–198
3. V. Stoytschew, M. Schulte-Borchers, I. Božičević Mihalić, R.D. Perez, New type of capillary for use as ion beam collimator and air-vacuum interface, Nucl. Instr. and Meth.B 380 (2016)
4. Nadia Abdul-Karim, Christopher S. Blackman, Philip P. Gill, Ruth M. Morgan, Lidija Matjacic, Roger Webb and Wing H. Ng, Morphological Variations of Explosive Residue Particles and Implications for Understanding Detonation Mechanisms, Anal. Chem., 2016, 88 (7), pp 3899–3908
6th SPRITE Management Meeting 27th – 28th June 2016
Manchester Cancer Research Centre (MCRC), Wilmslow Road, Manchester