1. Algorithm for the management of increased ICP
Algorithm for the management of increased ICP. aTreatment thresholds: ICP 20 to 29 mm Hg ( kPa) for >15 minutes; ICP 30 to 39 mm Hg ( kPa) for >2 minutes; ICP more than or equal to 40 mm Hg (≥5.3 kPa) for more than 1 minute. Note: Transient increases may occur following respiratory procedures (eg, suctioning, chest physiotherapy, bronchoscopy, and intubation). bHold if serum osmolality is more than 320 mOsm/kg (320 mmol/kg). cPartial pentobarbital loading dose (mg) = (30 mg/L – measured Cp) (1 L/kg × wt[kg]) (pentobarbital concentration in μmol/L must first be divided by to convert to mg/L). (Cp, plasma concentration; EEG, electroencephalogram; ICP, intracranial pressure; ICU, intensive care unit; OR, operating room; PaCO2, partial pressure of arterial blood carbon dioxide.) (Reprinted with permission from Wood CG, Boucher BA. Acute Management of the Traumatic Brain Injury Patient. In: Richardson M, Chant C, Chessman KH, et al., eds. Pharmacotherapy Self-Assessment Program, 7th ed. Neurology and Psychiatry. Lenexa, KS: American College of Clinical Pharmacy, 2012:143-4.)
Source: Acute Management of the Brain Injury Patient, Pharmacotherapy: A Pathophysiologic Approach, 10e
Citation: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. Pharmacotherapy: A Pathophysiologic Approach, 10e; 2017 Available at: Accessed: October 11, 2017
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