Presentation is loading. Please wait.

Presentation is loading. Please wait.

Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,

Published byTero Laine Modified over 6 years ago

Similar presentations

Presentation on theme: "Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,"— Presentation transcript:

1 Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method 
Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä, Laura Matilainen, Pekka Jarho, Johan Carlfors, Vesa‐Pekka Lehto, Tomi Järvinen, Kristiina Järvinen  Journal of Pharmaceutical Sciences  Volume 95, Issue 10, Pages (October 2006) DOI: /jps.20702 Copyright © 2006 Wiley‐Liss, Inc. Terms and Conditions

2 Figure 1 Schematic representation of the SEDS apparatus. (a) The coaxial nozzle (1) is connected to particle formation chamber (2) in a thermostated oven (3). (b) The solvent connections before the coaxial nozzle: conventional method (left) and modified method (right). Journal of Pharmaceutical Sciences  , DOI: ( /jps.20702) Copyright © 2006 Wiley‐Liss, Inc. Terms and Conditions

3 Figure 2 DSC thermograms of unprocessed and SEDS‐processed powders: unprocessed micronised budesonide (I), SEDS‐processed budesonide (100 bar, 60°C) (II), SEDS‐processed budesonide (100 bar, 80°C) (III), unprocessed physical mixture of budesonide and γ‐cyclodextrin (IV), precipitated budesonide/γ‐cyclodextrin complexes (V) and SEDS‐processed budesonide/γ‐cyclodextrin complexes (prepared with conventional method at 100 bar, 60°C) (VI). Journal of Pharmaceutical Sciences  , DOI: ( /jps.20702) Copyright © 2006 Wiley‐Liss, Inc. Terms and Conditions

4 Figure 3 Dissolution profiles of unprocessed micronised budesonide (black squares), SEDS‐processed budesonide (100 bar, 60°C) (black circles), unprocessed physical mixture of budesonide and γ‐cyclodextrin (grey triangles), precipitated budesonide/γ‐cyclodextrin complexes (black triangles) and SEDS‐processed budesonide/γ‐cyclodextrin complexes: conventional method 100 bar, 60°C (white squares) and modified method 100 bar, 60°C (white circles) (mean; n = 3–5). Data from Table 3. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20702) Copyright © 2006 Wiley‐Liss, Inc. Terms and Conditions

5 Figure 4 X‐ray powder diffractograms of unprocessed micronised budesonide (a), unprocessed γ‐cyclodextrin (b), unprocessed physical mixture of budesonide and γ‐cyclodextrin (c), precipitated budesonide/γ‐cyclodextrin complexes (d), SEDS‐processed budesonide/γ‐cyclodextrin complexes (prepared with conventional method at 100 bar, 60°C) (e), SEDS‐processed budesonide/γ‐cyclodextrin complexes (prepared with modified method at 100 bar, 60°C) (f). Journal of Pharmaceutical Sciences  , DOI: ( /jps.20702) Copyright © 2006 Wiley‐Liss, Inc. Terms and Conditions

6 Figure 5 SEM images of unprocessed, micronised budesonide (a), SEDS‐processed budesonide/γ‐cyclodextrin complexes; conventional method 100 bar, 60°C (b) and modified method 100 bar, 60°C (c). Image scale bar = 20 µm; inset scale bar = 5 µm. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20702) Copyright © 2006 Wiley‐Liss, Inc. Terms and Conditions

7 Figure 6 Effect of SEDS processing conditions on the complexation efficiency between budesonide and γ‐cyclodextrin. Journal of Pharmaceutical Sciences  , DOI: ( /jps.20702) Copyright © 2006 Wiley‐Liss, Inc. Terms and Conditions

Download ppt "Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,"

Similar presentations

I.1 ii.2 iii.3 iv.4 1+1=. i.1 ii.2 iii.3 iv.4 1+1=

I.1 ii.2 iii.3 iv.4 1+1=. i.1 ii.2 iii.3 iv.4 1+1=
I.1 ii.2 iii.3 iv.4 1+1=. i.1 ii.2 iii.3 iv.4 1+1=

I.1 ii.2 iii.3 iv.4 1+1=. i.1 ii.2 iii.3 iv.4 1+1=
Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages 234-244 (October.

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.
Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages 20-31 (January 2004) DOI: 10.3168/jds.S0022-0302(04)73137-9.

Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages (January 2004) DOI: /jds.S (04)
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages 332-384 (March.

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
Image Postprocessing in Digital Radiology—A Primer for Technologists Euclid Seeram, RTR, BSc, MSc, FCAMRT, David Seeram Journal of Medical Imaging and.

Image Postprocessing in Digital Radiology—A Primer for Technologists Euclid Seeram, RTR, BSc, MSc, FCAMRT, David Seeram Journal of Medical Imaging and.
Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.
Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid  Paula.

Solvent-Mediated Solid Phase Transformations of cArbamazepine: Effects of Simulated Intestinal Fluid and Fasted State Simulated Intestinal Fluid  Paula.
In Vivo Evaluation of 5-Fluorouracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery  Sheng-Rong Guo,

In Vivo Evaluation of 5-Fluorouracil-Containing Self-Expandable Nitinol Stent in Rabbits: Efficiency in Long-Term Local Drug Delivery  Sheng-Rong Guo,
The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance  Paul M. Young, Hak-kim Chan, Herbert Chiou,

The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance  Paul M. Young, Hak-kim Chan, Herbert Chiou,
Application of Powder X-ray Diffraction in Studying the Compaction Behavior of Bulk Pharmaceutical Powders  Rebanta Bandyopadhyay, Jon Selbo, Gregory.

Application of Powder X-ray Diffraction in Studying the Compaction Behavior of Bulk Pharmaceutical Powders  Rebanta Bandyopadhyay, Jon Selbo, Gregory.
Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies  Maurizio Ricci, Carmelo Puglia,

Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies  Maurizio Ricci, Carmelo Puglia,
Artificial Neural Network Prediction of the Patterns of Deposition of Polydisperse Aerosols Within Human Lungs  Javed Nazir, David J. Barlow, M. Jayne.

Artificial Neural Network Prediction of the Patterns of Deposition of Polydisperse Aerosols Within Human Lungs  Javed Nazir, David J. Barlow, M. Jayne.
Date of download: 10/12/2017 Copyright © ASME. All rights reserved.

Date of download: 10/12/2017 Copyright © ASME. All rights reserved.
Stabilization of Lysozyme by Benzyl Alcohol: Surface Tension and Thermodynamic Parameters  Monu Kumari Goyal, Ipsita Roy, Aeshna Amin, Uttam Chand Banerjee,

Stabilization of Lysozyme by Benzyl Alcohol: Surface Tension and Thermodynamic Parameters  Monu Kumari Goyal, Ipsita Roy, Aeshna Amin, Uttam Chand Banerjee,
Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,

Preparation of budesonide/γ‐cyclodextrin complexes in supercritical fluids with a novel SEDS method  Tarja Toropainen, Sitaram Velaga, Teemu Heikkilä,
Stabilization of Low Glass Transition Temperature Indomethacin Formulations: Impact of Polymer-Type and Its Concentration  Rina J. Chokshi, Navnit H.

Stabilization of Low Glass Transition Temperature Indomethacin Formulations: Impact of Polymer-Type and Its Concentration  Rina J. Chokshi, Navnit H.
Date of download: 10/15/2017 Copyright © ASME. All rights reserved.

Date of download: 10/15/2017 Copyright © ASME. All rights reserved.
Pediatric Drugs-A Review of Commercially Available Oral Formulations

Pediatric Drugs-A Review of Commercially Available Oral Formulations
In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin  Kristiina M. Huttunen, Jukka Leppänen, Jouko Vepsäläinen, Jouni Sirviö, Krista.

In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin  Kristiina M. Huttunen, Jukka Leppänen, Jouko Vepsäläinen, Jouni Sirviö, Krista.

Similar presentations

Ads by Google