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Figure 1 Simplified scheme of TGFβ signalling

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Presentation on theme: "Figure 1 Simplified scheme of TGFβ signalling"— Presentation transcript:

1 Figure 1 Simplified scheme of TGFβ signalling
Figure 1 | Simplified scheme of TGFβ signalling. Active transforming growth factor-β (TGFβ) dimers bind to the TGFβ type II receptor (TGFβRII) and recruits activin receptor-like kinase 5 (ALK5) and/or ALK1. This results in phosphorylation of SMAD2 or SMAD3 (via ALK5) or SMAD1, SMAD5 or SMAD8 (via ALK1).The phosphorylated SMADs bind to SMAD4, forming a trimeric complex, and translocate to the nucleus. These complexes accumulate in the nucleus and, together with co-activators and repressors, control transcriptional responses and regulate expression of specific genes. van der Kraan, P. M. (2017) The changing role of TGFβ in healthy, ageing and osteoarthritic joints Nat. Rev. Rheumatol. doi: /nrrheum

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