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Double peaked P1 visual evoked potentials in healthy ageing

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Presentation on theme: "Double peaked P1 visual evoked potentials in healthy ageing"— Presentation transcript:

1 Double peaked P1 visual evoked potentials in healthy ageing
G. Stothart, A. Tales, C. Hedge, N. Kazanina  Clinical Neurophysiology  Volume 125, Issue 7, Pages (July 2014) DOI: /j.clinph Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

2 Fig. 1 Stimuli used to elicit visual evoked potentials (a) inter-stimulus screen; (b) standard; (c) deviant; (d) target. Unless otherwise noted, the analyses in the current study are based only on standard stimuli. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

3 Fig. 2 Grand average responses to standard stimuli at the occipital region of interest (mean value of electrodes O1, Oz, O2, PO9, PO10, PO7 & PO8), for younger and older adults. The topographic map illustrates the location of the region of interest electrodes. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

4 Fig. 3 Individual VEPs to standard stimuli at the occipital region of interest (mean value of electrodes O1, Oz, O2, PO9, PO10, PO7 & PO8), split by P1 peak morphology classification. For each morphology group topographic maps illustrate the mean voltage distribution for the P1, P1a or P1b peak, re-referenced to a common average reference. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

5 Fig. 4 P1 peak morphology type as determined by expert classification.
Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

6 Fig. 5 Grand average waveforms to standard, deviant and target stimuli for older adults who displayed a double peaked P1 to standard stimuli (n=11) at the occipital region of interest (mean value of electrodes O1, Oz, O2, PO9, PO10, PO7 & PO8). Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

7 Fig. 6 Time–frequency plots of percentage change in overall and non-phase locked spectral power at electrode C6 compared to baseline (−200–0ms). A – Older adults with a double peaked P1. B – Older adults with a single peaked P1. C – Difference plot (A minus B). Significant differences, p<0.05 after Monte Carlo permutation correction for multiple comparisons, are masked in green. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

8 Supplementary Fig. 1 64 electrode grand average plots of responses to standard stimuli for younger and older adults, referenced to FCz and common average references. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions

9 Supplementary Fig. 2 64 channel plots illustrating the topographic distribution of significant differences in spectral power change compared to baseline (−200–0ms) of older adults with a double peaked P1 (n=11) and a single peaked P1 (n=10). Significant differences, p<0.05 after Monte Carlo permutation correction for multiple comparisons, are presented in green. Non-significant differences are masked in white. X and Y axes scales for all electrode plots are indicated by the blank plot at the bottom of the figure. Clinical Neurophysiology  , DOI: ( /j.clinph ) Copyright © 2013 International Federation of Clinical Neurophysiology Terms and Conditions


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